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Correlation Between Imaging Morphological Findings and Laboratory Biomarkers in Patients with Retinal Vein Occlusion

INTRODUCTION: The aim of this study was to investigate the possible correlation between peripheral blood biomarkers and morphological characteristics of retinal imaging in patients with retinal vein occlusion (RVO). METHODS: Participants in this cross-sectional observational study were 65 consecutiv...

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Autores principales: Kazantzis, Dimitrios, Sergentanis, Theodoros N., Machairoudia, Genovefa, Dimitriou, Eleni, Kroupis, Christos, Theodossiadis, George, Theodossiadis, Panagiotis, Chatziralli, Irini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011245/
https://www.ncbi.nlm.nih.gov/pubmed/36806996
http://dx.doi.org/10.1007/s40123-023-00677-1
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author Kazantzis, Dimitrios
Sergentanis, Theodoros N.
Machairoudia, Genovefa
Dimitriou, Eleni
Kroupis, Christos
Theodossiadis, George
Theodossiadis, Panagiotis
Chatziralli, Irini
author_facet Kazantzis, Dimitrios
Sergentanis, Theodoros N.
Machairoudia, Genovefa
Dimitriou, Eleni
Kroupis, Christos
Theodossiadis, George
Theodossiadis, Panagiotis
Chatziralli, Irini
author_sort Kazantzis, Dimitrios
collection PubMed
description INTRODUCTION: The aim of this study was to investigate the possible correlation between peripheral blood biomarkers and morphological characteristics of retinal imaging in patients with retinal vein occlusion (RVO). METHODS: Participants in this cross-sectional observational study were 65 consecutive patients (65 eyes) with treatment-naïve RVO, who underwent spectral-domain optical coherence tomography (SD-OCT) and fundus fluorescein angiography (FFA). In addition, peripheral blood samples were taken to evaluate full blood count and biochemical parameters. The association between imaging characteristics and laboratory parameters was examined. RESULTS: Eyes with subretinal fluid presented significantly higher neutrophil-to-lymphocyte ratios (p = 0.028). Hyperreflective foci on SD-OCT were found to be associated with higher triglyceride levels (p = 0.024). The presence of cysts on SD-OCT was associated with significantly higher triglycerides (p = 0.010). Central subfield thickness (CST) higher than 464 μm was associated with higher lymphocyte count (p = 0.016) and higher urea (p = 0.015). No significant associations were found between laboratory parameters and intraretinal fluid, ellipsoid zone and external limiting membrane condition, or epiretinal membrane and macular ischemia. CONCLUSIONS: Specific imaging morphological characteristics were found to be associated with laboratory parameters in patients with RVO. These findings may help reveal the pathophysiology of RVO and its correlation with the development of specific clinical signs, while they could guide individualized treatment.
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spelling pubmed-100112452023-03-15 Correlation Between Imaging Morphological Findings and Laboratory Biomarkers in Patients with Retinal Vein Occlusion Kazantzis, Dimitrios Sergentanis, Theodoros N. Machairoudia, Genovefa Dimitriou, Eleni Kroupis, Christos Theodossiadis, George Theodossiadis, Panagiotis Chatziralli, Irini Ophthalmol Ther Original Research INTRODUCTION: The aim of this study was to investigate the possible correlation between peripheral blood biomarkers and morphological characteristics of retinal imaging in patients with retinal vein occlusion (RVO). METHODS: Participants in this cross-sectional observational study were 65 consecutive patients (65 eyes) with treatment-naïve RVO, who underwent spectral-domain optical coherence tomography (SD-OCT) and fundus fluorescein angiography (FFA). In addition, peripheral blood samples were taken to evaluate full blood count and biochemical parameters. The association between imaging characteristics and laboratory parameters was examined. RESULTS: Eyes with subretinal fluid presented significantly higher neutrophil-to-lymphocyte ratios (p = 0.028). Hyperreflective foci on SD-OCT were found to be associated with higher triglyceride levels (p = 0.024). The presence of cysts on SD-OCT was associated with significantly higher triglycerides (p = 0.010). Central subfield thickness (CST) higher than 464 μm was associated with higher lymphocyte count (p = 0.016) and higher urea (p = 0.015). No significant associations were found between laboratory parameters and intraretinal fluid, ellipsoid zone and external limiting membrane condition, or epiretinal membrane and macular ischemia. CONCLUSIONS: Specific imaging morphological characteristics were found to be associated with laboratory parameters in patients with RVO. These findings may help reveal the pathophysiology of RVO and its correlation with the development of specific clinical signs, while they could guide individualized treatment. Springer Healthcare 2023-02-18 2023-04 /pmc/articles/PMC10011245/ /pubmed/36806996 http://dx.doi.org/10.1007/s40123-023-00677-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Original Research
Kazantzis, Dimitrios
Sergentanis, Theodoros N.
Machairoudia, Genovefa
Dimitriou, Eleni
Kroupis, Christos
Theodossiadis, George
Theodossiadis, Panagiotis
Chatziralli, Irini
Correlation Between Imaging Morphological Findings and Laboratory Biomarkers in Patients with Retinal Vein Occlusion
title Correlation Between Imaging Morphological Findings and Laboratory Biomarkers in Patients with Retinal Vein Occlusion
title_full Correlation Between Imaging Morphological Findings and Laboratory Biomarkers in Patients with Retinal Vein Occlusion
title_fullStr Correlation Between Imaging Morphological Findings and Laboratory Biomarkers in Patients with Retinal Vein Occlusion
title_full_unstemmed Correlation Between Imaging Morphological Findings and Laboratory Biomarkers in Patients with Retinal Vein Occlusion
title_short Correlation Between Imaging Morphological Findings and Laboratory Biomarkers in Patients with Retinal Vein Occlusion
title_sort correlation between imaging morphological findings and laboratory biomarkers in patients with retinal vein occlusion
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011245/
https://www.ncbi.nlm.nih.gov/pubmed/36806996
http://dx.doi.org/10.1007/s40123-023-00677-1
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