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Menopausal symptoms and quality of life in female survivors treated with hematopoietic stem cell transplantation

OBJECTIVES: To assess the severity of menopausal symptoms and the correlation among different quality of life questionnaires and compare the quality of life of patients who underwent hematopoietic stem cell transplantation (HSCT) for hematological disorders with the norm group in order to facilitate...

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Autores principales: Su, Huina, Li, Huiling, Zhang, Hua, Yang, Xin, Wang, Chaohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011465/
https://www.ncbi.nlm.nih.gov/pubmed/36926465
http://dx.doi.org/10.3389/fpsyt.2023.1050959
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author Su, Huina
Li, Huiling
Zhang, Hua
Yang, Xin
Wang, Chaohua
author_facet Su, Huina
Li, Huiling
Zhang, Hua
Yang, Xin
Wang, Chaohua
author_sort Su, Huina
collection PubMed
description OBJECTIVES: To assess the severity of menopausal symptoms and the correlation among different quality of life questionnaires and compare the quality of life of patients who underwent hematopoietic stem cell transplantation (HSCT) for hematological disorders with the norm group in order to facilitate personalized and directed therapeutic intervention for patients. METHODS: We recruited women who had premature ovarian failure (POF) after HSCT for hematologic diseases in the gynecological endocrinology outpatient clinic of Peking University People's Hospital. Women with HSCT were included in the study if they had 6 months of spontaneous amenorrhea with serum follicle-stimulating hormone levels greater than 40 mIU/mL taken 4 weeks apart. The patients who had other causes of POF were excluded. During the survey, all women were required to fill out the questionnaires [Quality of Life Questionnaire (MENQOL), Generalized Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-9 (PHQ-9), and 36-item Short-Form (SF-36)] online. We analyzed the severity of menopausal symptoms, anxiety, and depression in Participants. In addition, differences on the SF-36 scale scores between the study group and norm groups were examined. RESULTS: In total, 227 (93.41%) patients completed the survey and were analyzed. The severity of all symptoms is “none and mild” in MRS, MENQOL, GAD-7, and PHQ-9. On the MRS, the most common symptoms were irritability, physical and mental exhaustion, and sleep problems. The severest symptoms were sexual problems (53, 73.82%), followed by sleep problems (44, 19.38%) and mental and physical exhaustion (39, 17.18%). In the MENQOL, the most common symptoms were psychosocial and physical symptoms. The severest symptoms were sexual symptoms (35, 48.75%) followed by psychosocial symptoms (23, 10.13%). Moderate-severe scores were shown in 11.89% (27) and 18.72% (42) cases in the GAD-7 and PHQ-9, respectively. Based on SF-36, in comparison with the norm group, the HSCT participants had higher vitality scores and lower role physical, physical functioning, and role emotional scores aged 18–45. In addition, the HSCT participants had lower mental health scores aged 18–25, and lower general health scores aged 25–45. No strong correlation was observed between questionnaires in our study. CONCLUSION: Overall, menopausal symptoms are milder in female patients after HSCT. There is no single scale that comprehensively assesses the patient's quality of life after HSCT. We need to assess the severity of various symptoms in patients using different scales.
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spelling pubmed-100114652023-03-15 Menopausal symptoms and quality of life in female survivors treated with hematopoietic stem cell transplantation Su, Huina Li, Huiling Zhang, Hua Yang, Xin Wang, Chaohua Front Psychiatry Psychiatry OBJECTIVES: To assess the severity of menopausal symptoms and the correlation among different quality of life questionnaires and compare the quality of life of patients who underwent hematopoietic stem cell transplantation (HSCT) for hematological disorders with the norm group in order to facilitate personalized and directed therapeutic intervention for patients. METHODS: We recruited women who had premature ovarian failure (POF) after HSCT for hematologic diseases in the gynecological endocrinology outpatient clinic of Peking University People's Hospital. Women with HSCT were included in the study if they had 6 months of spontaneous amenorrhea with serum follicle-stimulating hormone levels greater than 40 mIU/mL taken 4 weeks apart. The patients who had other causes of POF were excluded. During the survey, all women were required to fill out the questionnaires [Quality of Life Questionnaire (MENQOL), Generalized Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-9 (PHQ-9), and 36-item Short-Form (SF-36)] online. We analyzed the severity of menopausal symptoms, anxiety, and depression in Participants. In addition, differences on the SF-36 scale scores between the study group and norm groups were examined. RESULTS: In total, 227 (93.41%) patients completed the survey and were analyzed. The severity of all symptoms is “none and mild” in MRS, MENQOL, GAD-7, and PHQ-9. On the MRS, the most common symptoms were irritability, physical and mental exhaustion, and sleep problems. The severest symptoms were sexual problems (53, 73.82%), followed by sleep problems (44, 19.38%) and mental and physical exhaustion (39, 17.18%). In the MENQOL, the most common symptoms were psychosocial and physical symptoms. The severest symptoms were sexual symptoms (35, 48.75%) followed by psychosocial symptoms (23, 10.13%). Moderate-severe scores were shown in 11.89% (27) and 18.72% (42) cases in the GAD-7 and PHQ-9, respectively. Based on SF-36, in comparison with the norm group, the HSCT participants had higher vitality scores and lower role physical, physical functioning, and role emotional scores aged 18–45. In addition, the HSCT participants had lower mental health scores aged 18–25, and lower general health scores aged 25–45. No strong correlation was observed between questionnaires in our study. CONCLUSION: Overall, menopausal symptoms are milder in female patients after HSCT. There is no single scale that comprehensively assesses the patient's quality of life after HSCT. We need to assess the severity of various symptoms in patients using different scales. Frontiers Media S.A. 2023-02-28 /pmc/articles/PMC10011465/ /pubmed/36926465 http://dx.doi.org/10.3389/fpsyt.2023.1050959 Text en Copyright © 2023 Su, Li, Zhang, Yang and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Su, Huina
Li, Huiling
Zhang, Hua
Yang, Xin
Wang, Chaohua
Menopausal symptoms and quality of life in female survivors treated with hematopoietic stem cell transplantation
title Menopausal symptoms and quality of life in female survivors treated with hematopoietic stem cell transplantation
title_full Menopausal symptoms and quality of life in female survivors treated with hematopoietic stem cell transplantation
title_fullStr Menopausal symptoms and quality of life in female survivors treated with hematopoietic stem cell transplantation
title_full_unstemmed Menopausal symptoms and quality of life in female survivors treated with hematopoietic stem cell transplantation
title_short Menopausal symptoms and quality of life in female survivors treated with hematopoietic stem cell transplantation
title_sort menopausal symptoms and quality of life in female survivors treated with hematopoietic stem cell transplantation
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011465/
https://www.ncbi.nlm.nih.gov/pubmed/36926465
http://dx.doi.org/10.3389/fpsyt.2023.1050959
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