Cholesteric liquid crystal biosensor platform with image analysis for rapid detection of COVID-19

Rapid and low-cost diagnosis of coronavirus disease 2019 (COVID-19) is essential to identify infected subjects, particularly asymptomatic cases, primarily to arrest the spread of the disease through local transmission. Antibody-based chromatographic serological tests, as an alternative to the RT-PCR...

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Autores principales: Lin, Ping-Yuan, Chung, Yi-Wei, Chuang, Er-Yuan, Wang, Yen-Chieh, Lai, Min-Chih, Hsu, Yen-Chin, Lin, Chun-Che, Hsiao, Yu-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011469/
https://www.ncbi.nlm.nih.gov/pubmed/36926691
http://dx.doi.org/10.3389/fbioe.2023.1148446
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author Lin, Ping-Yuan
Chung, Yi-Wei
Chuang, Er-Yuan
Wang, Yen-Chieh
Lai, Min-Chih
Hsu, Yen-Chin
Lin, Chun-Che
Hsiao, Yu-Cheng
author_facet Lin, Ping-Yuan
Chung, Yi-Wei
Chuang, Er-Yuan
Wang, Yen-Chieh
Lai, Min-Chih
Hsu, Yen-Chin
Lin, Chun-Che
Hsiao, Yu-Cheng
author_sort Lin, Ping-Yuan
collection PubMed
description Rapid and low-cost diagnosis of coronavirus disease 2019 (COVID-19) is essential to identify infected subjects, particularly asymptomatic cases, primarily to arrest the spread of the disease through local transmission. Antibody-based chromatographic serological tests, as an alternative to the RT-PCR technique, offer only limited help due to high false positives. We propose to exploit our cholesteric liquid crystal biosensor platform for one-step, wash-free, rapid detection of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus directly with minimal sample pre-processing. As mentioned above, cholesteric liquid crystals are an effective and innovative approach to healthcare as a rapid test for the diagnosis of COVID-19 and other diseases.
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spelling pubmed-100114692023-03-15 Cholesteric liquid crystal biosensor platform with image analysis for rapid detection of COVID-19 Lin, Ping-Yuan Chung, Yi-Wei Chuang, Er-Yuan Wang, Yen-Chieh Lai, Min-Chih Hsu, Yen-Chin Lin, Chun-Che Hsiao, Yu-Cheng Front Bioeng Biotechnol Bioengineering and Biotechnology Rapid and low-cost diagnosis of coronavirus disease 2019 (COVID-19) is essential to identify infected subjects, particularly asymptomatic cases, primarily to arrest the spread of the disease through local transmission. Antibody-based chromatographic serological tests, as an alternative to the RT-PCR technique, offer only limited help due to high false positives. We propose to exploit our cholesteric liquid crystal biosensor platform for one-step, wash-free, rapid detection of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus directly with minimal sample pre-processing. As mentioned above, cholesteric liquid crystals are an effective and innovative approach to healthcare as a rapid test for the diagnosis of COVID-19 and other diseases. Frontiers Media S.A. 2023-02-28 /pmc/articles/PMC10011469/ /pubmed/36926691 http://dx.doi.org/10.3389/fbioe.2023.1148446 Text en Copyright © 2023 Lin, Chung, Chuang, Wang, Lai, Hsu, Lin and Hsiao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Lin, Ping-Yuan
Chung, Yi-Wei
Chuang, Er-Yuan
Wang, Yen-Chieh
Lai, Min-Chih
Hsu, Yen-Chin
Lin, Chun-Che
Hsiao, Yu-Cheng
Cholesteric liquid crystal biosensor platform with image analysis for rapid detection of COVID-19
title Cholesteric liquid crystal biosensor platform with image analysis for rapid detection of COVID-19
title_full Cholesteric liquid crystal biosensor platform with image analysis for rapid detection of COVID-19
title_fullStr Cholesteric liquid crystal biosensor platform with image analysis for rapid detection of COVID-19
title_full_unstemmed Cholesteric liquid crystal biosensor platform with image analysis for rapid detection of COVID-19
title_short Cholesteric liquid crystal biosensor platform with image analysis for rapid detection of COVID-19
title_sort cholesteric liquid crystal biosensor platform with image analysis for rapid detection of covid-19
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011469/
https://www.ncbi.nlm.nih.gov/pubmed/36926691
http://dx.doi.org/10.3389/fbioe.2023.1148446
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