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Innate immune biology in age-related macular degeneration

Age-related macular degeneration (AMD) is a neurodegenerative disease and a leading cause of irreversible vision loss in the developed world. While not classically described as an inflammatory disease, a growing body of evidence has implicated several components of the innate immune system in the pa...

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Autores principales: Ascunce, Karina, Dhodapkar, Rahul M., Huang, Deven, Hafler, Brian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011475/
https://www.ncbi.nlm.nih.gov/pubmed/36926522
http://dx.doi.org/10.3389/fcell.2023.1118524
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author Ascunce, Karina
Dhodapkar, Rahul M.
Huang, Deven
Hafler, Brian P.
author_facet Ascunce, Karina
Dhodapkar, Rahul M.
Huang, Deven
Hafler, Brian P.
author_sort Ascunce, Karina
collection PubMed
description Age-related macular degeneration (AMD) is a neurodegenerative disease and a leading cause of irreversible vision loss in the developed world. While not classically described as an inflammatory disease, a growing body of evidence has implicated several components of the innate immune system in the pathophysiology of age-related macular degeneration. In particular, complement activation, microglial involvement, and blood-retinal-barrier disruption have been shown to play key roles in disease progression, and subsequent vision loss. This review discusses the role of the innate immune system in age-related macular degeneration as well as recent developments in single-cell transcriptomics that help advance the understanding and treatment of age-related macular degeneration. We also explore the several potential therapeutic targets for age-related macular degeneration in the context of innate immune activation.
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spelling pubmed-100114752023-03-15 Innate immune biology in age-related macular degeneration Ascunce, Karina Dhodapkar, Rahul M. Huang, Deven Hafler, Brian P. Front Cell Dev Biol Cell and Developmental Biology Age-related macular degeneration (AMD) is a neurodegenerative disease and a leading cause of irreversible vision loss in the developed world. While not classically described as an inflammatory disease, a growing body of evidence has implicated several components of the innate immune system in the pathophysiology of age-related macular degeneration. In particular, complement activation, microglial involvement, and blood-retinal-barrier disruption have been shown to play key roles in disease progression, and subsequent vision loss. This review discusses the role of the innate immune system in age-related macular degeneration as well as recent developments in single-cell transcriptomics that help advance the understanding and treatment of age-related macular degeneration. We also explore the several potential therapeutic targets for age-related macular degeneration in the context of innate immune activation. Frontiers Media S.A. 2023-02-28 /pmc/articles/PMC10011475/ /pubmed/36926522 http://dx.doi.org/10.3389/fcell.2023.1118524 Text en Copyright © 2023 Ascunce, Dhodapkar, Huang and Hafler. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Ascunce, Karina
Dhodapkar, Rahul M.
Huang, Deven
Hafler, Brian P.
Innate immune biology in age-related macular degeneration
title Innate immune biology in age-related macular degeneration
title_full Innate immune biology in age-related macular degeneration
title_fullStr Innate immune biology in age-related macular degeneration
title_full_unstemmed Innate immune biology in age-related macular degeneration
title_short Innate immune biology in age-related macular degeneration
title_sort innate immune biology in age-related macular degeneration
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011475/
https://www.ncbi.nlm.nih.gov/pubmed/36926522
http://dx.doi.org/10.3389/fcell.2023.1118524
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