Quantitative phosphoproteomic analysis reveals unique cAMP signaling pools emanating from AC2 and AC6 in human airway smooth muscle cells

Human airway smooth muscle (HASM) is the primary target of ßAR agonists used to control airway hypercontractility in asthma and chronic obstructive pulmonary disease (COPD). ßAR agonists induce the production of cAMP by adenylyl cyclases (ACs), activate PKA and cause bronchodilation. Several other G...

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Detalles Bibliográficos
Autores principales: Cattani-Cavalieri, Isabella, Li, Yue, Margolis, Jordyn, Bogard, Amy, Roosan, Moom R., Ostrom, Rennolds S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011497/
https://www.ncbi.nlm.nih.gov/pubmed/36926196
http://dx.doi.org/10.3389/fphys.2023.1149063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011497/
https://www.ncbi.nlm.nih.gov/pubmed/36926196
http://dx.doi.org/10.3389/fphys.2023.1149063

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