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BET inhibitor trotabresib in heavily pretreated patients with solid tumors and diffuse large B-cell lymphomas

Bromodomain and extraterminal proteins (BET) play key roles in regulation of gene expression, and may play a role in cancer-cell proliferation, survival, and oncogenic progression. CC-90010-ST-001 (NCT03220347) is an open-label phase I study of trotabresib, an oral BET inhibitor, in heavily pretreat...

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Detalles Bibliográficos
Autores principales:	Moreno, Victor, Vieito, Maria, Sepulveda, Juan Manuel, Galvao, Vladimir, Hernández-Guerrero, Tatiana, Doger, Bernard, Saavedra, Omar, Carlo-Stella, Carmelo, Michot, Jean-Marie, Italiano, Antoine, Magagnoli, Massimo, Carpio, Cecilia, Pinto, Antonio, Sarmiento, Rafael, Amoroso, Barbara, Aronchik, Ida, Filvaroff, Ellen, Hanna, Bishoy, Wei, Xin, Nikolova, Zariana, Braña, Irene
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011554/ https://www.ncbi.nlm.nih.gov/pubmed/36914652 http://dx.doi.org/10.1038/s41467-023-36976-1

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