Associations of dietary intakes of vitamins B(1) and B(3) with risk of mortality from CVD among Japanese men and women: the Japan Collaborative Cohort study

The evidence on the association between B vitamins and the risk of CVD is inconclusive. We aimed to examine the association of dietary vitamins B(1) and B(3) intakes with risk of CVD mortality among 58 302 Japanese men and women aged 40-79 years participated in the Japan Collaborative Cohort (JACC) study. The Cox proportional hazard model estimated the hazard ratios (HR) and 95% CI of CVD mortality across increasing energy-adjusted quintiles of dietary vitamins B(1) and B(3) intakes. During 960 225 person-years of follow-up, we documented a total of 3371 CVD deaths. After adjustment for age, sex, and other CVD risk factors, HR of mortality from ischemic heart disease, myocardial infarction, and heart failure in the highest v. lowest vitamin B(1) intake quintiles were 0.57 (95 % CI 0·40, 0·80; P(for trend) < 0·01), 0.56 (95 % CI 0·37, 0·82; P(for trend) < 0·01), and 0.65 (95 % CI 0·45, 0·96; P(for trend) = 0·13). The multivariable HR of myocardial infarction mortality in the highest v. lowest vitamin B(3) intake quintiles was 0.66 (95 % CI 0·48, 0·90; P(for trend) = 0·02). Atendency towards a reduced risk of haemorrhagic stroke mortality was observed with a higher dietary intake of vitamin B(3) (HR: 0·74 (95 % CI 0·55, 1·01)) but not vitamin B(1). In conclusion, higher dietary intakes of vitamins B(1) and B(3) were inversely associated with mortality from ischemic heart disease and a higher dietary intake of vitamin B(1) was inversely associated with a reduced risk of mortality from heart failure among Japanese men and women.