Polymerase θ inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in models of BRCA-deficient cancer

Recently developed inhibitors of polymerase theta (POLθ) have demonstrated synthetic lethality in BRCA-deficient tumor models. To examine the contribution of the immune microenvironment to antitumor efficacy, we characterized the effects of POLθ inhibition in immunocompetent models of BRCA1-deficien...

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Detalles Bibliográficos
Autores principales: Patterson-Fortin, Jeffrey, Jadhav, Heta, Pantelidou, Constantia, Phan, Tin, Grochala, Carter, Mehta, Anita K., Guerriero, Jennifer L., Wulf, Gerburg M., Wolpin, Brian M., Stanger, Ben Z., Aguirre, Andrew J., Cleary, James M., D’Andrea, Alan D., Shapiro, Geoffrey I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011609/
https://www.ncbi.nlm.nih.gov/pubmed/36914658
http://dx.doi.org/10.1038/s41467-023-37096-6

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