Four missense genetic variants in CUBN are associated with higher levels of eGFR in non-diabetes but not in diabetes mellitus or its subtypes: A genetic association study in Europeans

AIM: Rare genetic variants in the CUBN gene encoding the main albumin-transporter in the proximal tubule of the kidneys have previously been associated with microalbuminuria and higher urine albumin levels, also in diabetes. Sequencing studies in isolated proteinuria suggest that these variants migh...

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Autores principales: Uglebjerg, Nicoline, Ahmadizar, Fariba, Aly, Dina M., Cañadas-Garre, Marisa, Hill, Claire, Naber, Annemieke, Oddsson, Asmundur, Singh, Sunny S., Smyth, Laura, Trégouët, David-Alexandre, Chaker, Layal, Ghanbari, Mohsen, Steinthorsdottir, Valgerdur, Ahlqvist, Emma, Hadjadj, Samy, Van Hoek, Mandy, Kavousi, Maryam, McKnight, Amy Jayne, Sijbrands, Eric J., Stefansson, Kari, Simons, Matias, Rossing, Peter, Ahluwalia, Tarunveer S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011651/
https://www.ncbi.nlm.nih.gov/pubmed/36926036
http://dx.doi.org/10.3389/fendo.2023.1081741

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