Loss of ATF6α in a human carcinoma cell line is compensated not by its paralogue ATF6β but by sustained activation of the IRE1 and PERK arms for tumor growth in nude mice

To survive poor nutritional conditions, tumor cells activate the unfolded protein response, which is composed of the IRE1, PERK, and ATF6 arms, to maintain the homeostasis of the endoplasmic reticulum, where secretory and transmembrane proteins destined for the secretory pathway gain their correct t...

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Detalles Bibliográficos
Autores principales: Jin, Shengyu, Jin, Byungseok, Ishikawa, Tokiro, Ninagawa, Satoshi, Okada, Tetsuya, Koyasu, Sho, Harada, Hiroshi, Mori, Kazutoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011727/
https://www.ncbi.nlm.nih.gov/pubmed/36696173
http://dx.doi.org/10.1091/mbc.E22-07-0292

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