The genetic basis for adult-onset idiopathic dilated cardiomyopathy in people of African descent

Cardiomyopathies are a heterogeneous group of cardiac muscle disorders that result in dilated, hypertrophic, or restrictive pathophysiological entities. Dilated cardiomyopathy (DCM) is the most common form in sub-Saharan Africa (SSA). However, population-specific research studies reporting the actua...

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Autores principales: Tsabedze, Nqoba, Ramsay, Michele, Krause, Amanda, Wells, Quinn, Mpanya, Dineo, Manga, Pravin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011790/
https://www.ncbi.nlm.nih.gov/pubmed/36917398
http://dx.doi.org/10.1007/s10741-023-10302-9
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author Tsabedze, Nqoba
Ramsay, Michele
Krause, Amanda
Wells, Quinn
Mpanya, Dineo
Manga, Pravin
author_facet Tsabedze, Nqoba
Ramsay, Michele
Krause, Amanda
Wells, Quinn
Mpanya, Dineo
Manga, Pravin
author_sort Tsabedze, Nqoba
collection PubMed
description Cardiomyopathies are a heterogeneous group of cardiac muscle disorders that result in dilated, hypertrophic, or restrictive pathophysiological entities. Dilated cardiomyopathy (DCM) is the most common form in sub-Saharan Africa (SSA). However, population-specific research studies reporting the actual burden of DCM in this region are still lacking. Also, little is known about the genetic basis of DCM in this population, and genetic testing is still not readily accessible. This review describes the common pathogenic genes implicated in DCM globally and discusses the evidence-based management of patients with DCM. We also present a summary of studies describing genes implicated or associated with DCM in patients residing in SSA. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10741-023-10302-9.
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spelling pubmed-100117902023-03-14 The genetic basis for adult-onset idiopathic dilated cardiomyopathy in people of African descent Tsabedze, Nqoba Ramsay, Michele Krause, Amanda Wells, Quinn Mpanya, Dineo Manga, Pravin Heart Fail Rev Article Cardiomyopathies are a heterogeneous group of cardiac muscle disorders that result in dilated, hypertrophic, or restrictive pathophysiological entities. Dilated cardiomyopathy (DCM) is the most common form in sub-Saharan Africa (SSA). However, population-specific research studies reporting the actual burden of DCM in this region are still lacking. Also, little is known about the genetic basis of DCM in this population, and genetic testing is still not readily accessible. This review describes the common pathogenic genes implicated in DCM globally and discusses the evidence-based management of patients with DCM. We also present a summary of studies describing genes implicated or associated with DCM in patients residing in SSA. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10741-023-10302-9. Springer US 2023-03-14 2023 /pmc/articles/PMC10011790/ /pubmed/36917398 http://dx.doi.org/10.1007/s10741-023-10302-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Tsabedze, Nqoba
Ramsay, Michele
Krause, Amanda
Wells, Quinn
Mpanya, Dineo
Manga, Pravin
The genetic basis for adult-onset idiopathic dilated cardiomyopathy in people of African descent
title The genetic basis for adult-onset idiopathic dilated cardiomyopathy in people of African descent
title_full The genetic basis for adult-onset idiopathic dilated cardiomyopathy in people of African descent
title_fullStr The genetic basis for adult-onset idiopathic dilated cardiomyopathy in people of African descent
title_full_unstemmed The genetic basis for adult-onset idiopathic dilated cardiomyopathy in people of African descent
title_short The genetic basis for adult-onset idiopathic dilated cardiomyopathy in people of African descent
title_sort genetic basis for adult-onset idiopathic dilated cardiomyopathy in people of african descent
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011790/
https://www.ncbi.nlm.nih.gov/pubmed/36917398
http://dx.doi.org/10.1007/s10741-023-10302-9
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