The systemic inhibition of the terminal complement system reduces neuroinflammation but does not improve motor function in mouse models of CMT1A with overexpressed PMP22

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most prevalent hereditary demyelinating neuropathy. This autosomal, dominantly inherited disease is caused by a duplication on chromosome 17p which includes the peripheral myelin protein 22 (PMP22) gene. There is clinical evidence that the disabilit...

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Detalles Bibliográficos
Autores principales: Michailidou, Iliana, Vreijling, Jeroen, Rumpf, Matthijs, Loos, Maarten, Koopmans, Bastijn, Vlek, Nina, Straat, Nina, Agaser, Cedrick, Kuipers, Thomas B., Mei, Hailiang, Baas, Frank, Fluiter, Kees
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011818/
https://www.ncbi.nlm.nih.gov/pubmed/36926597
http://dx.doi.org/10.1016/j.crneur.2023.100077

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