The mTORC2/AKT/VCP axis is associated with quality control of the stalled translation of poly(GR) dipeptide repeats in C9-ALS/FTD

Expansion of G4C2 hexanucleotide repeats in the chromosome 9 ORF 72 (C9ORF72) gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS) with frontotemporal dementia (C9-ALS/FTD). Dipeptide repeats generated by unconventional translation, especially the R-containing poly(GR), have...

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Detalles Bibliográficos
Autores principales: Li, Yu, Geng, Ji, Rimal, Suman, Wang, Haochuan, Liu, Xiangguo, Lu, Bingwei, Li, Shuangxi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011831/
https://www.ncbi.nlm.nih.gov/pubmed/36764521
http://dx.doi.org/10.1016/j.jbc.2023.102995

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