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Neurocognitive Functions in Patients with Comorbid Hepatitis C and Opioid Dependence: A Comparative Study

BACKGROUND: Hepatitis C virus (HCV) infection is commonly comorbid with opioid dependence (OD). We wanted to compare the neurocognitive functions of OD subjects with or without HCV [HCV (+), HCV (–)] and healthy controls (HC). METHODS: We recruited 40 adult subjects (age 18–55 years) in each group....

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Autores principales: Ghosh, Abhishek, Mahintamani, Tathagata, Rana, Devender K., Basu, Debasish, Mattoo, Surendra Kumar, Premkumar, Madhumita, Singh, Geetesh Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011847/
https://www.ncbi.nlm.nih.gov/pubmed/36925501
http://dx.doi.org/10.1177/02537176221127449
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author Ghosh, Abhishek
Mahintamani, Tathagata
Rana, Devender K.
Basu, Debasish
Mattoo, Surendra Kumar
Premkumar, Madhumita
Singh, Geetesh Kumar
author_facet Ghosh, Abhishek
Mahintamani, Tathagata
Rana, Devender K.
Basu, Debasish
Mattoo, Surendra Kumar
Premkumar, Madhumita
Singh, Geetesh Kumar
author_sort Ghosh, Abhishek
collection PubMed
description BACKGROUND: Hepatitis C virus (HCV) infection is commonly comorbid with opioid dependence (OD). We wanted to compare the neurocognitive functions of OD subjects with or without HCV [HCV (+), HCV (–)] and healthy controls (HC). METHODS: We recruited 40 adult subjects (age 18–55 years) in each group. HCV(+) group had a detectable viral load. Subjects with HIV or hepatitis B infection, head injury, epilepsy, or comorbid mental illness were excluded. We administered Standard Progressive Matrices (SPM), Wisconsin Card Sorting Test, Iowa Gambling Task (IGT), trail-making tests A and B, and verbal and visual N-back tests (NBT) one week after opioid abstinence. The group differences in cognitive performance were adjusted for age and years of education. Effect size (ES) is expressed as Cohen’s D. RESULTS: The HCV(+) and HCV(–) groups did not differ in potential effect modifiers (age and years of education) or confounders (age of opioid initiation, duration of use, dependence severity, tobacco use, and cannabis use) of neuropsychological functioning. HCV(+) showed significantly poorer performance than HCV(–) in SPM (P = 0.006; ES = 0.72). Both HCV(+) and HCV(–) performed worse than controls in IGT(P < 0.001; ES = 0.8) and visual NBT[P < 0.01 and ES > 1 for total errors]; HCV(+) had a larger ES of group difference than HCV(–). HCV(+) had higher error scores in verbal NBT than control. CONCLUSION: HCV(+) has poorer general intellectual ability and reasoning than HCV(–) persons and controls. Chronic HCV infection causes a higher magnitude of dysfunction in decision-making and visual working memory in opioid-dependent individuals.
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spelling pubmed-100118472023-03-15 Neurocognitive Functions in Patients with Comorbid Hepatitis C and Opioid Dependence: A Comparative Study Ghosh, Abhishek Mahintamani, Tathagata Rana, Devender K. Basu, Debasish Mattoo, Surendra Kumar Premkumar, Madhumita Singh, Geetesh Kumar Indian J Psychol Med Original Articles BACKGROUND: Hepatitis C virus (HCV) infection is commonly comorbid with opioid dependence (OD). We wanted to compare the neurocognitive functions of OD subjects with or without HCV [HCV (+), HCV (–)] and healthy controls (HC). METHODS: We recruited 40 adult subjects (age 18–55 years) in each group. HCV(+) group had a detectable viral load. Subjects with HIV or hepatitis B infection, head injury, epilepsy, or comorbid mental illness were excluded. We administered Standard Progressive Matrices (SPM), Wisconsin Card Sorting Test, Iowa Gambling Task (IGT), trail-making tests A and B, and verbal and visual N-back tests (NBT) one week after opioid abstinence. The group differences in cognitive performance were adjusted for age and years of education. Effect size (ES) is expressed as Cohen’s D. RESULTS: The HCV(+) and HCV(–) groups did not differ in potential effect modifiers (age and years of education) or confounders (age of opioid initiation, duration of use, dependence severity, tobacco use, and cannabis use) of neuropsychological functioning. HCV(+) showed significantly poorer performance than HCV(–) in SPM (P = 0.006; ES = 0.72). Both HCV(+) and HCV(–) performed worse than controls in IGT(P < 0.001; ES = 0.8) and visual NBT[P < 0.01 and ES > 1 for total errors]; HCV(+) had a larger ES of group difference than HCV(–). HCV(+) had higher error scores in verbal NBT than control. CONCLUSION: HCV(+) has poorer general intellectual ability and reasoning than HCV(–) persons and controls. Chronic HCV infection causes a higher magnitude of dysfunction in decision-making and visual working memory in opioid-dependent individuals. SAGE Publications 2022-10-27 2023-03 /pmc/articles/PMC10011847/ /pubmed/36925501 http://dx.doi.org/10.1177/02537176221127449 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Articles
Ghosh, Abhishek
Mahintamani, Tathagata
Rana, Devender K.
Basu, Debasish
Mattoo, Surendra Kumar
Premkumar, Madhumita
Singh, Geetesh Kumar
Neurocognitive Functions in Patients with Comorbid Hepatitis C and Opioid Dependence: A Comparative Study
title Neurocognitive Functions in Patients with Comorbid Hepatitis C and Opioid Dependence: A Comparative Study
title_full Neurocognitive Functions in Patients with Comorbid Hepatitis C and Opioid Dependence: A Comparative Study
title_fullStr Neurocognitive Functions in Patients with Comorbid Hepatitis C and Opioid Dependence: A Comparative Study
title_full_unstemmed Neurocognitive Functions in Patients with Comorbid Hepatitis C and Opioid Dependence: A Comparative Study
title_short Neurocognitive Functions in Patients with Comorbid Hepatitis C and Opioid Dependence: A Comparative Study
title_sort neurocognitive functions in patients with comorbid hepatitis c and opioid dependence: a comparative study
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011847/
https://www.ncbi.nlm.nih.gov/pubmed/36925501
http://dx.doi.org/10.1177/02537176221127449
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