Genetic Heterogeneity and Tissue-specific Patterns of Tumors with Multiple PIK3CA Mutations

PURPOSE: To comprehensively characterize tissue-specific and molecular subclasses of multiple PIK3CA (multi-PIK3CA) mutations and assess their impact on potential therapeutic outcomes. EXPERIMENTAL DESIGN: We profiled a pan-cancer cohort comprised of 352,392 samples across 66 tumor types using a tar...

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Detalles Bibliográficos
Autores principales: Sivakumar, Smruthy, Jin, Dexter X., Rathod, Ruchita, Ross, Jeffrey, Cantley, Lewis C., Scaltriti, Maurizio, Chen, Jessica W., Hutchinson, Katherine E., Wilson, Timothy R., Sokol, Ethan S., Vasan, Neil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Translational Cancer Mechanisms and Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011881/
https://www.ncbi.nlm.nih.gov/pubmed/36595567
http://dx.doi.org/10.1158/1078-0432.CCR-22-2270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011881/
https://www.ncbi.nlm.nih.gov/pubmed/36595567
http://dx.doi.org/10.1158/1078-0432.CCR-22-2270

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