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Modulatory effect of caffeic acid in alleviating diabetes and associated complications

Diabetes mellitus (DM) is one of the most common metabolic disorders characterized by elevated blood glucose levels. Prolonged uncontrolled hyperglycemia often leads to multi-organ damage including diabetic neuropathy, nephropathy, retinopathy, cardiovascular disorders, and diabetic foot ulcers. Exc...

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Autores principales: Ganguly, Risha, Singh, Shiv Vardan, Jaiswal, Kritika, Kumar, Ramesh, Pandey, Abhay K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011896/
https://www.ncbi.nlm.nih.gov/pubmed/36926656
http://dx.doi.org/10.4239/wjd.v14.i2.62
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author Ganguly, Risha
Singh, Shiv Vardan
Jaiswal, Kritika
Kumar, Ramesh
Pandey, Abhay K
author_facet Ganguly, Risha
Singh, Shiv Vardan
Jaiswal, Kritika
Kumar, Ramesh
Pandey, Abhay K
author_sort Ganguly, Risha
collection PubMed
description Diabetes mellitus (DM) is one of the most common metabolic disorders characterized by elevated blood glucose levels. Prolonged uncontrolled hyperglycemia often leads to multi-organ damage including diabetic neuropathy, nephropathy, retinopathy, cardiovascular disorders, and diabetic foot ulcers. Excess production of free radicals causing oxidative stress in tissues is often considered to be the primary cause of onset and progression of DM and associated complications. Natural polyphenols can be used to induce or inhibit the expression of antioxidant enzymes such as glutathione peroxidase, heme oxygenase-1, superoxide dismutase, and catalase that are essential in maintaining redox balance, and ameliorate oxidative stress. Caffeic acid (CA) is a polyphenolderived from hydroxycinnamic acid and possesses numerous physiological properties includ-ing antioxidant, anti-inflammatory, anti-atherosclerotic, immune-stimulatory, cardioprotective, antiproliferative, and hepatoprotective activities. CA acts as a regulatory compound affecting numerous biochemical pathways and multiple targets. These include various transcription factors such as nuclear factor-B, tumor necrosis factor-α, interleukin-6, cyclooxygenase-2, and nuclear factor erythroid 2-related factor 2. Therefore, this review summarizes the pharmacological properties, molecular mechanisms, and pharmacokinetic profile of CA in mitigating the adverse effects of DM and associated complications. The bioavailability, drug delivery, and clinical trials of CA have also been discussed.
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spelling pubmed-100118962023-03-15 Modulatory effect of caffeic acid in alleviating diabetes and associated complications Ganguly, Risha Singh, Shiv Vardan Jaiswal, Kritika Kumar, Ramesh Pandey, Abhay K World J Diabetes Review Diabetes mellitus (DM) is one of the most common metabolic disorders characterized by elevated blood glucose levels. Prolonged uncontrolled hyperglycemia often leads to multi-organ damage including diabetic neuropathy, nephropathy, retinopathy, cardiovascular disorders, and diabetic foot ulcers. Excess production of free radicals causing oxidative stress in tissues is often considered to be the primary cause of onset and progression of DM and associated complications. Natural polyphenols can be used to induce or inhibit the expression of antioxidant enzymes such as glutathione peroxidase, heme oxygenase-1, superoxide dismutase, and catalase that are essential in maintaining redox balance, and ameliorate oxidative stress. Caffeic acid (CA) is a polyphenolderived from hydroxycinnamic acid and possesses numerous physiological properties includ-ing antioxidant, anti-inflammatory, anti-atherosclerotic, immune-stimulatory, cardioprotective, antiproliferative, and hepatoprotective activities. CA acts as a regulatory compound affecting numerous biochemical pathways and multiple targets. These include various transcription factors such as nuclear factor-B, tumor necrosis factor-α, interleukin-6, cyclooxygenase-2, and nuclear factor erythroid 2-related factor 2. Therefore, this review summarizes the pharmacological properties, molecular mechanisms, and pharmacokinetic profile of CA in mitigating the adverse effects of DM and associated complications. The bioavailability, drug delivery, and clinical trials of CA have also been discussed. Baishideng Publishing Group Inc 2023-02-15 2023-02-15 /pmc/articles/PMC10011896/ /pubmed/36926656 http://dx.doi.org/10.4239/wjd.v14.i2.62 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Review
Ganguly, Risha
Singh, Shiv Vardan
Jaiswal, Kritika
Kumar, Ramesh
Pandey, Abhay K
Modulatory effect of caffeic acid in alleviating diabetes and associated complications
title Modulatory effect of caffeic acid in alleviating diabetes and associated complications
title_full Modulatory effect of caffeic acid in alleviating diabetes and associated complications
title_fullStr Modulatory effect of caffeic acid in alleviating diabetes and associated complications
title_full_unstemmed Modulatory effect of caffeic acid in alleviating diabetes and associated complications
title_short Modulatory effect of caffeic acid in alleviating diabetes and associated complications
title_sort modulatory effect of caffeic acid in alleviating diabetes and associated complications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011896/
https://www.ncbi.nlm.nih.gov/pubmed/36926656
http://dx.doi.org/10.4239/wjd.v14.i2.62
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