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Outcomes of gout in patients with cirrhosis: A national inpatient sample-based study
BACKGROUND: Hyperuricemia is a prerequisite for the development of gout. Elevated serum uric acid (UA) levels result from either overproduction or decreased excretion. A positive correlation between serum UA levels, cirrhosis-related complications and the incidence of nonalcoholic fatty liver diseas...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Baishideng Publishing Group Inc
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011910/ https://www.ncbi.nlm.nih.gov/pubmed/36926244 http://dx.doi.org/10.4254/wjh.v15.i2.303 |
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author | Khrais, Ayham Kahlam, Aaron Tahir, Ali Shaikh, Amjad Ahlawat, Sushil |
author_facet | Khrais, Ayham Kahlam, Aaron Tahir, Ali Shaikh, Amjad Ahlawat, Sushil |
author_sort | Khrais, Ayham |
collection | PubMed |
description | BACKGROUND: Hyperuricemia is a prerequisite for the development of gout. Elevated serum uric acid (UA) levels result from either overproduction or decreased excretion. A positive correlation between serum UA levels, cirrhosis-related complications and the incidence of nonalcoholic fatty liver disease has been established, but it is unknown whether hyperuricemia results in worsening cirrhosis outcomes. We hypothesize that patients with cirrhosis will have poorer gout outcomes. AIM: To explore the link between cirrhosis and the incidence of gout-related complications. METHODS: This was a cross-sectional study. The national inpatient sample was used to identify patients hospitalized with gout, stratified based on a history of cirrhosis, from 2001 to 2013 via the International Classification of Diseases, Ninth Revision, Clinical Modification codes. Primary outcomes were mortality, gout complications and joint interventions. The χ(2) test and independent t-test were performed to assess categorical and continuous data, respectively. Multiple logistic regression was used to control for confounding variables. RESULTS: Patients without cirrhosis were older (70.37 ± 13.53 years vs 66.21 ± 12.325 years; P < 0.05). Most patients were male (74.63% in the cirrhosis group vs 66.83%; adjusted P < 0.05). Patients with cirrhosis had greater rates of mortality (5.49% vs 2.03%; adjusted P < 0.05), gout flare (2.89% vs 2.77%; adjusted P < 0.05) and tophi (0.97% vs 0.75%; adjusted P = 0.677). Patients without cirrhosis had higher rates of arthrocentesis (2.45% vs 2.21%; adjusted P < 0.05) and joint injections (0.72% vs 0.52%; adjusted P < 0.05). CONCLUSION: Gout complications were more common in cirrhosis. Those without cirrhosis had higher rates of interventions, possibly due to hesitancy with performing these interventions given the higher complication risk in cirrhosis. |
format | Online Article Text |
id | pubmed-10011910 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-100119102023-03-15 Outcomes of gout in patients with cirrhosis: A national inpatient sample-based study Khrais, Ayham Kahlam, Aaron Tahir, Ali Shaikh, Amjad Ahlawat, Sushil World J Hepatol Observational Study BACKGROUND: Hyperuricemia is a prerequisite for the development of gout. Elevated serum uric acid (UA) levels result from either overproduction or decreased excretion. A positive correlation between serum UA levels, cirrhosis-related complications and the incidence of nonalcoholic fatty liver disease has been established, but it is unknown whether hyperuricemia results in worsening cirrhosis outcomes. We hypothesize that patients with cirrhosis will have poorer gout outcomes. AIM: To explore the link between cirrhosis and the incidence of gout-related complications. METHODS: This was a cross-sectional study. The national inpatient sample was used to identify patients hospitalized with gout, stratified based on a history of cirrhosis, from 2001 to 2013 via the International Classification of Diseases, Ninth Revision, Clinical Modification codes. Primary outcomes were mortality, gout complications and joint interventions. The χ(2) test and independent t-test were performed to assess categorical and continuous data, respectively. Multiple logistic regression was used to control for confounding variables. RESULTS: Patients without cirrhosis were older (70.37 ± 13.53 years vs 66.21 ± 12.325 years; P < 0.05). Most patients were male (74.63% in the cirrhosis group vs 66.83%; adjusted P < 0.05). Patients with cirrhosis had greater rates of mortality (5.49% vs 2.03%; adjusted P < 0.05), gout flare (2.89% vs 2.77%; adjusted P < 0.05) and tophi (0.97% vs 0.75%; adjusted P = 0.677). Patients without cirrhosis had higher rates of arthrocentesis (2.45% vs 2.21%; adjusted P < 0.05) and joint injections (0.72% vs 0.52%; adjusted P < 0.05). CONCLUSION: Gout complications were more common in cirrhosis. Those without cirrhosis had higher rates of interventions, possibly due to hesitancy with performing these interventions given the higher complication risk in cirrhosis. Baishideng Publishing Group Inc 2023-02-27 2023-02-27 /pmc/articles/PMC10011910/ /pubmed/36926244 http://dx.doi.org/10.4254/wjh.v15.i2.303 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Observational Study Khrais, Ayham Kahlam, Aaron Tahir, Ali Shaikh, Amjad Ahlawat, Sushil Outcomes of gout in patients with cirrhosis: A national inpatient sample-based study |
title | Outcomes of gout in patients with cirrhosis: A national inpatient sample-based study |
title_full | Outcomes of gout in patients with cirrhosis: A national inpatient sample-based study |
title_fullStr | Outcomes of gout in patients with cirrhosis: A national inpatient sample-based study |
title_full_unstemmed | Outcomes of gout in patients with cirrhosis: A national inpatient sample-based study |
title_short | Outcomes of gout in patients with cirrhosis: A national inpatient sample-based study |
title_sort | outcomes of gout in patients with cirrhosis: a national inpatient sample-based study |
topic | Observational Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011910/ https://www.ncbi.nlm.nih.gov/pubmed/36926244 http://dx.doi.org/10.4254/wjh.v15.i2.303 |
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