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Stress hyperglycemia, Diabetes mellitus and COVID-19 infection: The impact on newly diagnosed type 1 diabetes

Several recent studies have documented an increased incidence of newly diagnosed type 1 Diabetes (T1D) cases in children and adolescents during the COVID-19 pandemic and a more severe presentation at diabetes onset. In this descriptive study, we present the experience of the Diabetes Centre of the D...

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Autores principales: Farakla, Ioanna, Lagousi, Theano, Miligkos, Michael, Nicolaides, Nicolas C., Vasilakis, Ioannis-Anargyros, Mpinou, Maria, Dolianiti, Maria, Katechaki, Elina, Taliou, Anilia, Spoulou, Vasiliki, Kanaka-Gantenbein, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012074/
https://www.ncbi.nlm.nih.gov/pubmed/36992762
http://dx.doi.org/10.3389/fcdhc.2022.818945
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author Farakla, Ioanna
Lagousi, Theano
Miligkos, Michael
Nicolaides, Nicolas C.
Vasilakis, Ioannis-Anargyros
Mpinou, Maria
Dolianiti, Maria
Katechaki, Elina
Taliou, Anilia
Spoulou, Vasiliki
Kanaka-Gantenbein, Christina
author_facet Farakla, Ioanna
Lagousi, Theano
Miligkos, Michael
Nicolaides, Nicolas C.
Vasilakis, Ioannis-Anargyros
Mpinou, Maria
Dolianiti, Maria
Katechaki, Elina
Taliou, Anilia
Spoulou, Vasiliki
Kanaka-Gantenbein, Christina
author_sort Farakla, Ioanna
collection PubMed
description Several recent studies have documented an increased incidence of newly diagnosed type 1 Diabetes (T1D) cases in children and adolescents during the COVID-19 pandemic and a more severe presentation at diabetes onset. In this descriptive study, we present the experience of the Diabetes Centre of the Division of Endocrinology, Diabetes, and Metabolism of the First Department of Pediatrics of the National and Kapodistrian University of Athens Medical School at “Aghia Sophia” Children’s Hospital in Athens, Greece, concerning new cases of T1D diagnosis during the COVID-19 pandemic (March 2020- December 2021). Patients who had already been diagnosed with T1D and needed hospitalization due to poor control during the pandemic have been excluded from this study. Eighty- three children and adolescents with a mean age of 8,5 ± 4.02 years were admitted to the hospital due to newly diagnosed T1D during this 22 months’ period in comparison to 34 new cases in the previous year. All patients admitted during the pandemic with a new diagnosis of T1D, presented in their majority with DKA (Ph: 7.2) representing an increase of new severe cases in comparison to previous years (Ph 7.2 versus 7.3, p value: 0.021, in the previous year), [p-value: 0.027]. 49 cases presented with DKA, of which 24 were characterized moderate and 14 severe DKA (28.9% and 16,9%, respectively), while 5 patients newly diagnosed, needed to be admitted to the ICU to recover from severe acidosis. Whether a previous COVID- 19 infection could have been the triggering factor is not supported by the SARS-Cov2 specific antibodies analysis in our cohort of patients. As far as HbA1c is concerned there was no statistically significant difference between the pre COVID-19 year and the years of the pandemic (11.6% versus 11.9%, p- value: 0.461). Triglycerides values were significantly higher in patients with new onset T1D during COVID-19 years compared to those before the pandemic (p value= 0.032). Additionally, there is a statistically significant correlation between Ph and Triglycerides for the whole period 2020-2021 (p-value<0.001), while this correlation is not significant for the year 2019. More large- scale studies are required to confirm these observations.
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spelling pubmed-100120742023-03-28 Stress hyperglycemia, Diabetes mellitus and COVID-19 infection: The impact on newly diagnosed type 1 diabetes Farakla, Ioanna Lagousi, Theano Miligkos, Michael Nicolaides, Nicolas C. Vasilakis, Ioannis-Anargyros Mpinou, Maria Dolianiti, Maria Katechaki, Elina Taliou, Anilia Spoulou, Vasiliki Kanaka-Gantenbein, Christina Front Clin Diabetes Healthc Clinical Diabetes and Healthcare Several recent studies have documented an increased incidence of newly diagnosed type 1 Diabetes (T1D) cases in children and adolescents during the COVID-19 pandemic and a more severe presentation at diabetes onset. In this descriptive study, we present the experience of the Diabetes Centre of the Division of Endocrinology, Diabetes, and Metabolism of the First Department of Pediatrics of the National and Kapodistrian University of Athens Medical School at “Aghia Sophia” Children’s Hospital in Athens, Greece, concerning new cases of T1D diagnosis during the COVID-19 pandemic (March 2020- December 2021). Patients who had already been diagnosed with T1D and needed hospitalization due to poor control during the pandemic have been excluded from this study. Eighty- three children and adolescents with a mean age of 8,5 ± 4.02 years were admitted to the hospital due to newly diagnosed T1D during this 22 months’ period in comparison to 34 new cases in the previous year. All patients admitted during the pandemic with a new diagnosis of T1D, presented in their majority with DKA (Ph: 7.2) representing an increase of new severe cases in comparison to previous years (Ph 7.2 versus 7.3, p value: 0.021, in the previous year), [p-value: 0.027]. 49 cases presented with DKA, of which 24 were characterized moderate and 14 severe DKA (28.9% and 16,9%, respectively), while 5 patients newly diagnosed, needed to be admitted to the ICU to recover from severe acidosis. Whether a previous COVID- 19 infection could have been the triggering factor is not supported by the SARS-Cov2 specific antibodies analysis in our cohort of patients. As far as HbA1c is concerned there was no statistically significant difference between the pre COVID-19 year and the years of the pandemic (11.6% versus 11.9%, p- value: 0.461). Triglycerides values were significantly higher in patients with new onset T1D during COVID-19 years compared to those before the pandemic (p value= 0.032). Additionally, there is a statistically significant correlation between Ph and Triglycerides for the whole period 2020-2021 (p-value<0.001), while this correlation is not significant for the year 2019. More large- scale studies are required to confirm these observations. Frontiers Media S.A. 2022-08-29 /pmc/articles/PMC10012074/ /pubmed/36992762 http://dx.doi.org/10.3389/fcdhc.2022.818945 Text en Copyright © 2022 Farakla, Lagousi, Miligkos, Nicolaides, Vasilakis, Mpinou, Dolianiti, Katechaki, Taliou, Spoulou and Kanaka-Gantenbein https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Clinical Diabetes and Healthcare
Farakla, Ioanna
Lagousi, Theano
Miligkos, Michael
Nicolaides, Nicolas C.
Vasilakis, Ioannis-Anargyros
Mpinou, Maria
Dolianiti, Maria
Katechaki, Elina
Taliou, Anilia
Spoulou, Vasiliki
Kanaka-Gantenbein, Christina
Stress hyperglycemia, Diabetes mellitus and COVID-19 infection: The impact on newly diagnosed type 1 diabetes
title Stress hyperglycemia, Diabetes mellitus and COVID-19 infection: The impact on newly diagnosed type 1 diabetes
title_full Stress hyperglycemia, Diabetes mellitus and COVID-19 infection: The impact on newly diagnosed type 1 diabetes
title_fullStr Stress hyperglycemia, Diabetes mellitus and COVID-19 infection: The impact on newly diagnosed type 1 diabetes
title_full_unstemmed Stress hyperglycemia, Diabetes mellitus and COVID-19 infection: The impact on newly diagnosed type 1 diabetes
title_short Stress hyperglycemia, Diabetes mellitus and COVID-19 infection: The impact on newly diagnosed type 1 diabetes
title_sort stress hyperglycemia, diabetes mellitus and covid-19 infection: the impact on newly diagnosed type 1 diabetes
topic Clinical Diabetes and Healthcare
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012074/
https://www.ncbi.nlm.nih.gov/pubmed/36992762
http://dx.doi.org/10.3389/fcdhc.2022.818945
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