7-N-Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome bc(1) Complex

[Image: see text] The development of new antimalarials is required because of the threat of resistance to current antimalarial therapies. To discover new antimalarial chemotypes, we screened the Janssen Jumpstarter library against the P. falciparum asexual parasite and identified the 7-N-substituted...

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Detalles Bibliográficos
Autores principales: Nguyen, William, Dans, Madeline G., Currie, Iain, Awalt, Jon Kyle, Bailey, Brodie L., Lumb, Chris, Ngo, Anna, Favuzza, Paola, Palandri, Josephine, Ramesh, Saishyam, Penington, Jocelyn, Jarman, Kate E., Mukherjee, Partha, Chakraborty, Arnish, Maier, Alexander G., van Dooren, Giel G., Papenfuss, Tony, Wittlin, Sergio, Churchyard, Alisje, Baum, Jake, Winzeler, Elizabeth A., Baud, Delphine, Brand, Stephen, Jackson, Paul F., Cowman, Alan F., Sleebs, Brad E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012268/
https://www.ncbi.nlm.nih.gov/pubmed/36853190
http://dx.doi.org/10.1021/acsinfecdis.2c00607

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