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Mechanical force induces macrophage-derived exosomal UCHL3 promoting bone marrow mesenchymal stem cell osteogenesis by targeting SMAD1

BACKGROUND: Orthodontic tooth movement (OTM), a process of alveolar bone remodelling, is induced by mechanical force and regulated by local inflammation. Bone marrow-derived mesenchymal stem cells (BMSCs) play a fundamental role in osteogenesis during OTM. Macrophages are mechanosensitive cells that...

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Detalles Bibliográficos
Autores principales:	Pu, Panjun, Wu, Shengnan, Zhang, Kejia, Xu, Hao, Guan, Jiani, Jin, Zhichun, Sun, Wen, Zhang, Hanwen, Yan, Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012474/ https://www.ncbi.nlm.nih.gov/pubmed/36915132 http://dx.doi.org/10.1186/s12951-023-01836-z

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