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Metformin regulates chondrocyte senescence and proliferation through microRNA-34a/SIRT1 pathway in osteoarthritis

BACKGROUND: Osteoarthritis (OA) is the most common degenerative disease in joints among elderly patients. Senescence is deeply involved in the pathogenesis of osteoarthritis. Metformin is widely used as the first-line drug for Type 2 diabetes mellitus (T2DM), and has great potential for the treatmen...

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Detalles Bibliográficos
Autores principales:	Yan, Shiju, Dong, Wenjing, Li, Zhirui, Wei, Junqiang, Han, Tao, Wang, Junliang, Lin, Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012483/ https://www.ncbi.nlm.nih.gov/pubmed/36915137 http://dx.doi.org/10.1186/s13018-023-03571-5

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