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Plasma exosome-derived connexin43 as a promising biomarker for melanoma patients

BACKGROUND: To examine the levels of exosome-derived connexin 43 (Cx43) in plasma and estimate its forecast value in patients with melanoma. METHODS: We measured the plasma exosome-derived Cx43 levels in the plasma of 112 melanoma patients and 50 healthy controls. RESULTS: The plasma exosome-derived...

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Autores principales: Shen, Yue, Li, Ming, Liao, Li, Gao, Suyue, Wang, Yongzhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012581/
https://www.ncbi.nlm.nih.gov/pubmed/36918803
http://dx.doi.org/10.1186/s12885-023-10705-9
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author Shen, Yue
Li, Ming
Liao, Li
Gao, Suyue
Wang, Yongzhen
author_facet Shen, Yue
Li, Ming
Liao, Li
Gao, Suyue
Wang, Yongzhen
author_sort Shen, Yue
collection PubMed
description BACKGROUND: To examine the levels of exosome-derived connexin 43 (Cx43) in plasma and estimate its forecast value in patients with melanoma. METHODS: We measured the plasma exosome-derived Cx43 levels in the plasma of 112 melanoma patients and 50 healthy controls. RESULTS: The plasma exosome-derived Cx43 levels in patients with melanoma were substantially downregulated as opposed to the levels in healthy controls (P < 0.001). Kaplan–Meier analysis indicated that overall survival (OS) and disease-free survival (DFS) were poorer in patients with melanoma who exhibited lower levels of plasma exosome-derived Cx43 (both P < 0.001). The levels of plasma exosome-derived Cx43 were considerably elevated in patients with melanoma whose tumor was situated in the skin, tumor size < 10 cm, with Clark level I–III, TNM stages IIb–IV, and had no lymph node metastasis as opposed to patients whose tumor was situated in the viscera or mucosa, tumor size ≥ 10 cm, Clark level IV–V, TNM stages IIb–IV and had lymph node metastasis (all P < 0.05). The receiver operating characteristic (ROC) of plasma exosome-derived Cx43 for forecasting 5-year DFS in patients with melanoma was 0.78 (95% confidence interval (CI): 0.70–0.86), with a specificity of 77.78% and a sensitivity of 81.55%. The ROC of plasma exosome-derived Cx43 for forecasting 5-year OS of patients with melanoma was 0.77 (95% CI: 0.68–0.84), with a specificity of 80.0% and sensitivity of 65.98%. CONCLUSION: The overall findings indicated that the levels of plasma exosome-derived Cx43 in patients with melanoma were considerably downregulated. It can therefore be inferred that the levels of plasma exosome-derived Cx43 might be a prospective prognostic indicator for 5 5-year OS and 5-year DFS of patients with melanoma. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-023-10705-9.
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spelling pubmed-100125812023-03-15 Plasma exosome-derived connexin43 as a promising biomarker for melanoma patients Shen, Yue Li, Ming Liao, Li Gao, Suyue Wang, Yongzhen BMC Cancer Research BACKGROUND: To examine the levels of exosome-derived connexin 43 (Cx43) in plasma and estimate its forecast value in patients with melanoma. METHODS: We measured the plasma exosome-derived Cx43 levels in the plasma of 112 melanoma patients and 50 healthy controls. RESULTS: The plasma exosome-derived Cx43 levels in patients with melanoma were substantially downregulated as opposed to the levels in healthy controls (P < 0.001). Kaplan–Meier analysis indicated that overall survival (OS) and disease-free survival (DFS) were poorer in patients with melanoma who exhibited lower levels of plasma exosome-derived Cx43 (both P < 0.001). The levels of plasma exosome-derived Cx43 were considerably elevated in patients with melanoma whose tumor was situated in the skin, tumor size < 10 cm, with Clark level I–III, TNM stages IIb–IV, and had no lymph node metastasis as opposed to patients whose tumor was situated in the viscera or mucosa, tumor size ≥ 10 cm, Clark level IV–V, TNM stages IIb–IV and had lymph node metastasis (all P < 0.05). The receiver operating characteristic (ROC) of plasma exosome-derived Cx43 for forecasting 5-year DFS in patients with melanoma was 0.78 (95% confidence interval (CI): 0.70–0.86), with a specificity of 77.78% and a sensitivity of 81.55%. The ROC of plasma exosome-derived Cx43 for forecasting 5-year OS of patients with melanoma was 0.77 (95% CI: 0.68–0.84), with a specificity of 80.0% and sensitivity of 65.98%. CONCLUSION: The overall findings indicated that the levels of plasma exosome-derived Cx43 in patients with melanoma were considerably downregulated. It can therefore be inferred that the levels of plasma exosome-derived Cx43 might be a prospective prognostic indicator for 5 5-year OS and 5-year DFS of patients with melanoma. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-023-10705-9. BioMed Central 2023-03-14 /pmc/articles/PMC10012581/ /pubmed/36918803 http://dx.doi.org/10.1186/s12885-023-10705-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Shen, Yue
Li, Ming
Liao, Li
Gao, Suyue
Wang, Yongzhen
Plasma exosome-derived connexin43 as a promising biomarker for melanoma patients
title Plasma exosome-derived connexin43 as a promising biomarker for melanoma patients
title_full Plasma exosome-derived connexin43 as a promising biomarker for melanoma patients
title_fullStr Plasma exosome-derived connexin43 as a promising biomarker for melanoma patients
title_full_unstemmed Plasma exosome-derived connexin43 as a promising biomarker for melanoma patients
title_short Plasma exosome-derived connexin43 as a promising biomarker for melanoma patients
title_sort plasma exosome-derived connexin43 as a promising biomarker for melanoma patients
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012581/
https://www.ncbi.nlm.nih.gov/pubmed/36918803
http://dx.doi.org/10.1186/s12885-023-10705-9
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