Cargando…

α-Synuclein conformers reveal link to clinical heterogeneity of α-synucleinopathies

α-Synucleinopathies, such as Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy, are a class of neurodegenerative diseases exhibiting intracellular inclusions of misfolded α-synuclein (αSyn), referred to as Lewy bodies or oligodendroglial cytoplasmic inclusions (Pa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schmitz, Matthias, Candelise, Niccolò, Canaslan, Sezgi, Altmeppen, Hermann C., Matschke, Jakob, Glatzel, Markus, Younas, Neelam, Zafar, Saima, Hermann, Peter, Zerr, Inga
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012698/ https://www.ncbi.nlm.nih.gov/pubmed/36915212 http://dx.doi.org/10.1186/s40035-023-00342-4

Ejemplares similares

Prion protein oligomers cause neuronal cytoskeletal damage in rapidly progressive Alzheimer’s disease
por: Shafiq, Mohsin, et al.
Publicado: (2021)

Detection of Cerebrospinal Fluid Neurofilament Light Chain as a Marker for Alpha-Synucleinopathies
por: Canaslan, Sezgi, et al.
Publicado: (2021)

Effect of the micro-environment on α-synuclein conversion and implication in seeded conversion assays
por: Candelise, Niccolo, et al.
Publicado: (2020)

α-Synuclein Strains: Does Amyloid Conformation Explain the Heterogeneity of Synucleinopathies?
por: Hoppe, Simon Oliver, et al.
Publicado: (2021)

The Interplay between α-Synuclein and Microglia in α-Synucleinopathies
por: Deyell, Jacob S., et al.
Publicado: (2023)

Drug Targeting of α-Synuclein Oligomerization in Synucleinopathies
por: Outeiro, Tiago Fleming, et al.
Publicado: (2008)

Conformation-specific Antibodies Targeting Aggregated Forms of α-synuclein Block the Propagation of Synucleinopathy
por: Choi, Minsun, et al.
Publicado: (2022)

α-Synuclein interacts directly but reversibly with psychosine: implications for α-synucleinopathies
por: Abdelkarim, Hazem, et al.
Publicado: (2018)

Pathogenic Impact of α-Synuclein Phosphorylation and Its Kinases in α-Synucleinopathies
por: Kawahata, Ichiro, et al.
Publicado: (2022)

Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations
por: de Boni, Laura, et al.
Publicado: (2022)

Propagative α-synuclein seeds as serum biomarkers for synucleinopathies
por: Okuzumi, Ayami, et al.
Publicado: (2023)

α-Synuclein oligomers and fibrils: partners in crime in synucleinopathies
por: Bigi, Alessandra, et al.
Publicado: (2023)

Cellular Milieu Imparts Distinct Pathological α-Synuclein Strains in α-Synucleinopathies
por: Peng, Chao, et al.
Publicado: (2018)

Low CSF Levels of Both α-Synuclein and the α-Synuclein Cleaving Enzyme Neurosin in Patients with Synucleinopathy
por: Wennström, Malin, et al.
Publicado: (2013)

Triggering of Inflammasome by Aggregated α–Synuclein, an Inflammatory Response in Synucleinopathies
por: Codolo, Gaia, et al.
Publicado: (2013)

Adenosine A1 receptor ligands bind to α-synuclein: implications for α-synuclein misfolding and α-synucleinopathy in Parkinson’s disease
por: Jakova, Elisabet, et al.
Publicado: (2022)

Possible Alterations in β-Synuclein, the Non-Amyloidogenic Homologue of α-Synuclein, during Progression of Sporadic α-Synucleinopathies
por: Fujita, Masayo, et al.
Publicado: (2012)

α-Synuclein pathology in post-mortem retina and optic nerve is specific for α-synucleinopathies
por: Hart de Ruyter, Frederique J., et al.
Publicado: (2023)

Genetic Variants Associated with the Age of Onset Identified by Whole-Exome Sequencing in Fatal Familial Insomnia
por: Thüne, Katrin, et al.
Publicado: (2023)

Tau Enhances α-Synuclein Aggregation and Toxicity in Cellular Models of Synucleinopathy
por: Badiola, Nahuai, et al.
Publicado: (2011)

Lovastatin Alleviates α-Synuclein Aggregation and Phosphorylation in Cellular Models of Synucleinopathy
por: Dai, Lijun, et al.
Publicado: (2021)

Lipotoxicity Downstream of α-Synuclein Imbalance: A Relevant Pathomechanism in Synucleinopathies?
por: Tripathi, Arati, et al.
Publicado: (2021)

Differential interactome mapping of aggregation prone/prion-like proteins under stress: novel links to stress granule biology
por: Younas, Neelam, et al.
Publicado: (2023)

AAV-mediated expression of a new conformational anti-aggregated α-synuclein antibody prolongs survival in a genetic model of α-synucleinopathies
por: Düchs, Matthias, et al.
Publicado: (2023)

Gut Microbiome-Modified Polyphenolic Compounds Inhibit α-Synuclein Seeding and Spreading in α-Synucleinopathies
por: Yamasaki, Tritia R., et al.
Publicado: (2020)

Modeling α-Synucleinopathy in Organotypic Brain Slice Culture with Preformed α-Synuclein Amyloid Fibrils
por: Roux, Amandine, et al.
Publicado: (2020)

Unveiling the Physical and Functional Niches of FAM26F by Analyzing Its Subcellular Localization and Novel Interacting Partners
por: Malik, Uzma, et al.
Publicado: (2020)

α-Synuclein Transgenic Drosophila As a Model of Parkinson's Disease and Related Synucleinopathies
por: Mizuno, Hideya, et al.
Publicado: (2010)

Role of α- and β-Synucleins in the Axonal Pathology of Parkinson’s Disease and Related Synucleinopathies
por: Sekigawa, Akio, et al.
Publicado: (2015)

Skin α-synuclein deposits differ in clinical variants of synucleinopathy: an in vivo study
por: Donadio, V., et al.
Publicado: (2018)

In Search of Effective Treatments Targeting α-Synuclein Toxicity in Synucleinopathies: Pros and Cons
por: Fouka, Maria, et al.
Publicado: (2020)

A glutaminyl cyclase-catalyzed α-synuclein modification identified in human synucleinopathies
por: Hartlage-Rübsamen, Maike, et al.
Publicado: (2021)

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
por: Luk, Kelvin C., et al.
Publicado: (2012)

Increased Neuronal α-Synuclein Pathology Associates with Its Accumulation in Oligodendrocytes in Mice Modeling α-Synucleinopathies
por: Kisos, Haya, et al.
Publicado: (2012)

Autonomic ganglionic injection of α-synuclein fibrils as a model of pure autonomic failure α-synucleinopathy
por: Wang, Xue-Jing, et al.
Publicado: (2020)

Lymphocyte Activation Gene 3 (Lag3) Contributes to α-Synucleinopathy in α-Synuclein Transgenic Mice
por: Gu, Hao, et al.
Publicado: (2021)

Development of α-Synuclein Real-Time Quaking-Induced Conversion as a Diagnostic Method for α-Synucleinopathies
por: Nakagaki, Takehiro, et al.
Publicado: (2021)

Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models
por: Prieto Huarcaya, Susy, et al.
Publicado: (2022)

Validation of α-Synuclein as a CSF Biomarker for Sporadic Creutzfeldt-Jakob Disease
por: Llorens, Franc, et al.
Publicado: (2017)

Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy
por: Spencer, Brian, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_s4u4b22dppmch22i6lqfuga0he