Insight into the conserved structural dynamics of the C-terminus of mammal PrPC identifies structural core and possible structural role of pharmacological chaperones

Misfolding of the prion protein is central to prion disease aetiology. Although understanding the dynamics of the native fold helps to decipher the conformational conversion mechanism, a complete depiction of distal but coupled prion protein sites common across species is lacking. To fill this gap,...

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Detalles Bibliográficos
Autores principales: Soto, Patricia, Gloeb, Garrett M., Tsuchida, Kaitlin A., Charles, Austin A., Greenwood, Noah M., Hendrickson, Heidi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012922/
https://www.ncbi.nlm.nih.gov/pubmed/36892160
http://dx.doi.org/10.1080/19336896.2023.2186674

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