The role of the sex hormone-gut microbiome axis in tumor immunotherapy

Accumulating evidence suggested that both gut microbiome and sex play a critical role in the efficacy of immune checkpoint blockade therapy. Considering the reciprocal relationship between sex hormones and gut microbiome, the sex hormone-gut microbiome axis may participate in the regulation of the r...

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Autores principales: Wang, Luoyang, Tang, Lei, Zhai, Dongchang, Song, Meiying, Li, Wei, Xu, Shuo, Jiang, Suli, Meng, Haining, Liang, Jie, Wang, Yingying, Zhang, Bei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012946/
https://www.ncbi.nlm.nih.gov/pubmed/36880651
http://dx.doi.org/10.1080/19490976.2023.2185035
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author Wang, Luoyang
Tang, Lei
Zhai, Dongchang
Song, Meiying
Li, Wei
Xu, Shuo
Jiang, Suli
Meng, Haining
Liang, Jie
Wang, Yingying
Zhang, Bei
author_facet Wang, Luoyang
Tang, Lei
Zhai, Dongchang
Song, Meiying
Li, Wei
Xu, Shuo
Jiang, Suli
Meng, Haining
Liang, Jie
Wang, Yingying
Zhang, Bei
author_sort Wang, Luoyang
collection PubMed
description Accumulating evidence suggested that both gut microbiome and sex play a critical role in the efficacy of immune checkpoint blockade therapy. Considering the reciprocal relationship between sex hormones and gut microbiome, the sex hormone-gut microbiome axis may participate in the regulation of the response to immune checkpoint inhibitors (ICIs). In this review, it was attempted to summarize the current knowledge about the influences of both sex and gut microbiome on the antitumor efficacy of ICIs and describe the interaction between sex hormones and gut microbiome. Accordingly, this review discussed the potential of enhancing the antitumor efficacy of ICIs through regulating the levels of sex hormones through manipulation of gut microbiome. Collectively, this review provided reliable evidence concerning the role of the sex hormone-gut microbiome axis in tumor immunotherapy.
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spelling pubmed-100129462023-03-15 The role of the sex hormone-gut microbiome axis in tumor immunotherapy Wang, Luoyang Tang, Lei Zhai, Dongchang Song, Meiying Li, Wei Xu, Shuo Jiang, Suli Meng, Haining Liang, Jie Wang, Yingying Zhang, Bei Gut Microbes Review Accumulating evidence suggested that both gut microbiome and sex play a critical role in the efficacy of immune checkpoint blockade therapy. Considering the reciprocal relationship between sex hormones and gut microbiome, the sex hormone-gut microbiome axis may participate in the regulation of the response to immune checkpoint inhibitors (ICIs). In this review, it was attempted to summarize the current knowledge about the influences of both sex and gut microbiome on the antitumor efficacy of ICIs and describe the interaction between sex hormones and gut microbiome. Accordingly, this review discussed the potential of enhancing the antitumor efficacy of ICIs through regulating the levels of sex hormones through manipulation of gut microbiome. Collectively, this review provided reliable evidence concerning the role of the sex hormone-gut microbiome axis in tumor immunotherapy. Taylor & Francis 2023-03-07 /pmc/articles/PMC10012946/ /pubmed/36880651 http://dx.doi.org/10.1080/19490976.2023.2185035 Text en © 2023 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Wang, Luoyang
Tang, Lei
Zhai, Dongchang
Song, Meiying
Li, Wei
Xu, Shuo
Jiang, Suli
Meng, Haining
Liang, Jie
Wang, Yingying
Zhang, Bei
The role of the sex hormone-gut microbiome axis in tumor immunotherapy
title The role of the sex hormone-gut microbiome axis in tumor immunotherapy
title_full The role of the sex hormone-gut microbiome axis in tumor immunotherapy
title_fullStr The role of the sex hormone-gut microbiome axis in tumor immunotherapy
title_full_unstemmed The role of the sex hormone-gut microbiome axis in tumor immunotherapy
title_short The role of the sex hormone-gut microbiome axis in tumor immunotherapy
title_sort role of the sex hormone-gut microbiome axis in tumor immunotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012946/
https://www.ncbi.nlm.nih.gov/pubmed/36880651
http://dx.doi.org/10.1080/19490976.2023.2185035
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