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Inter-muscular networks of synchronous muscle fiber activation

Skeletal muscles continuously coordinate to facilitate a wide range of movements. Muscle fiber composition and timing of activation account for distinct muscle functions and dynamics necessary to fine tune muscle coordination and generate movements. Here we address the fundamental question of how di...

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Detalles Bibliográficos
Autores principales: Garcia-Retortillo, Sergi, Ivanov, Plamen Ch.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012969/
https://www.ncbi.nlm.nih.gov/pubmed/36926057
http://dx.doi.org/10.3389/fnetp.2022.1059793
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author Garcia-Retortillo, Sergi
Ivanov, Plamen Ch.
author_facet Garcia-Retortillo, Sergi
Ivanov, Plamen Ch.
author_sort Garcia-Retortillo, Sergi
collection PubMed
description Skeletal muscles continuously coordinate to facilitate a wide range of movements. Muscle fiber composition and timing of activation account for distinct muscle functions and dynamics necessary to fine tune muscle coordination and generate movements. Here we address the fundamental question of how distinct muscle fiber types dynamically synchronize and integrate as a network across muscles with different functions. We uncover that physiological states are characterized by unique inter-muscular network of muscle fiber cross-frequency interactions with hierarchical organization of distinct sub-networks and modules, and a stratification profile of links strength specific for each state. We establish how this network reorganizes with transition from rest to exercise and fatigue—a complex process where network modules follow distinct phase-space trajectories reflecting their functional role in movements and adaptation to fatigue. This opens a new area of research, Network Physiology of Exercise, leading to novel network-based biomarkers of health, fitness and clinical conditions.
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spelling pubmed-100129692023-03-15 Inter-muscular networks of synchronous muscle fiber activation Garcia-Retortillo, Sergi Ivanov, Plamen Ch. Front Netw Physiol Network Physiology Skeletal muscles continuously coordinate to facilitate a wide range of movements. Muscle fiber composition and timing of activation account for distinct muscle functions and dynamics necessary to fine tune muscle coordination and generate movements. Here we address the fundamental question of how distinct muscle fiber types dynamically synchronize and integrate as a network across muscles with different functions. We uncover that physiological states are characterized by unique inter-muscular network of muscle fiber cross-frequency interactions with hierarchical organization of distinct sub-networks and modules, and a stratification profile of links strength specific for each state. We establish how this network reorganizes with transition from rest to exercise and fatigue—a complex process where network modules follow distinct phase-space trajectories reflecting their functional role in movements and adaptation to fatigue. This opens a new area of research, Network Physiology of Exercise, leading to novel network-based biomarkers of health, fitness and clinical conditions. Frontiers Media S.A. 2022-11-14 /pmc/articles/PMC10012969/ /pubmed/36926057 http://dx.doi.org/10.3389/fnetp.2022.1059793 Text en Copyright © 2022 Garcia-Retortillo and Ivanov. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Network Physiology
Garcia-Retortillo, Sergi
Ivanov, Plamen Ch.
Inter-muscular networks of synchronous muscle fiber activation
title Inter-muscular networks of synchronous muscle fiber activation
title_full Inter-muscular networks of synchronous muscle fiber activation
title_fullStr Inter-muscular networks of synchronous muscle fiber activation
title_full_unstemmed Inter-muscular networks of synchronous muscle fiber activation
title_short Inter-muscular networks of synchronous muscle fiber activation
title_sort inter-muscular networks of synchronous muscle fiber activation
topic Network Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012969/
https://www.ncbi.nlm.nih.gov/pubmed/36926057
http://dx.doi.org/10.3389/fnetp.2022.1059793
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