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Perspectives on Understanding Aberrant Brain Networks in Epilepsy
Epilepsy is a neurological disorder affecting approximately 70 million people worldwide. It is characterized by seizures that are complex aberrant dynamical events typically treated with drugs and surgery. Unfortunately, not all patients become seizure-free, and there is an opportunity for novel app...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013006/ https://www.ncbi.nlm.nih.gov/pubmed/36926081 http://dx.doi.org/10.3389/fnetp.2022.868092 |
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author | Sinha, Nishant Joshi, Rasesh B. Sandhu, Mani Ratnesh S. Netoff, Theoden I. Zaveri, Hitten P. Lehnertz, Klaus |
author_facet | Sinha, Nishant Joshi, Rasesh B. Sandhu, Mani Ratnesh S. Netoff, Theoden I. Zaveri, Hitten P. Lehnertz, Klaus |
author_sort | Sinha, Nishant |
collection | PubMed |
description | Epilepsy is a neurological disorder affecting approximately 70 million people worldwide. It is characterized by seizures that are complex aberrant dynamical events typically treated with drugs and surgery. Unfortunately, not all patients become seizure-free, and there is an opportunity for novel approaches to treat epilepsy using a network view of the brain. The traditional seizure focus theory presumed that seizures originated within a discrete cortical area with subsequent recruitment of adjacent cortices with seizure progression. However, a more recent view challenges this concept, suggesting that epilepsy is a network disease, and both focal and generalized seizures arise from aberrant activity in a distributed network. Changes in the anatomical configuration or widespread neural activities spanning lobes and hemispheres could make the brain more susceptible to seizures. In this perspective paper, we summarize the current state of knowledge, address several important challenges that could further improve our understanding of the human brain in epilepsy, and invite novel studies addressing these challenges. |
format | Online Article Text |
id | pubmed-10013006 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100130062023-03-15 Perspectives on Understanding Aberrant Brain Networks in Epilepsy Sinha, Nishant Joshi, Rasesh B. Sandhu, Mani Ratnesh S. Netoff, Theoden I. Zaveri, Hitten P. Lehnertz, Klaus Front Netw Physiol Network Physiology Epilepsy is a neurological disorder affecting approximately 70 million people worldwide. It is characterized by seizures that are complex aberrant dynamical events typically treated with drugs and surgery. Unfortunately, not all patients become seizure-free, and there is an opportunity for novel approaches to treat epilepsy using a network view of the brain. The traditional seizure focus theory presumed that seizures originated within a discrete cortical area with subsequent recruitment of adjacent cortices with seizure progression. However, a more recent view challenges this concept, suggesting that epilepsy is a network disease, and both focal and generalized seizures arise from aberrant activity in a distributed network. Changes in the anatomical configuration or widespread neural activities spanning lobes and hemispheres could make the brain more susceptible to seizures. In this perspective paper, we summarize the current state of knowledge, address several important challenges that could further improve our understanding of the human brain in epilepsy, and invite novel studies addressing these challenges. Frontiers Media S.A. 2022-04-05 /pmc/articles/PMC10013006/ /pubmed/36926081 http://dx.doi.org/10.3389/fnetp.2022.868092 Text en Copyright © 2022 Sinha, Joshi, Sandhu, Netoff, Zaveri and Lehnertz. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Network Physiology Sinha, Nishant Joshi, Rasesh B. Sandhu, Mani Ratnesh S. Netoff, Theoden I. Zaveri, Hitten P. Lehnertz, Klaus Perspectives on Understanding Aberrant Brain Networks in Epilepsy |
title | Perspectives on Understanding Aberrant Brain Networks in Epilepsy |
title_full | Perspectives on Understanding Aberrant Brain Networks in Epilepsy |
title_fullStr | Perspectives on Understanding Aberrant Brain Networks in Epilepsy |
title_full_unstemmed | Perspectives on Understanding Aberrant Brain Networks in Epilepsy |
title_short | Perspectives on Understanding Aberrant Brain Networks in Epilepsy |
title_sort | perspectives on understanding aberrant brain networks in epilepsy |
topic | Network Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013006/ https://www.ncbi.nlm.nih.gov/pubmed/36926081 http://dx.doi.org/10.3389/fnetp.2022.868092 |
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