Subtherapeutic Exposure of Ganciclovir in Children Despite Appropriate Dosing: A Short Communication

Therapeutic drug monitoring (TDM) results for ganciclovir in 12 different treatment episodes showed large intraindividual and interindividual variabilities in the trough concentration and area under the 24-hour concentration–time curve (AUC24). Despite adequate valganciclovir dosing, subtherapeutic...

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Detalles Bibliográficos
Autores principales: Marfil, Sjanene, Märtson, Anne-Grete, Toren-Wielema, Marlous, Leer-Buter, Coretta, Schölvinck, Elisabeth H., Alffenaar, Jan-Willem C., Touw, Daan J., Sturkenboom, Marieke G. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Therapeutic Drug Monitoring 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013166/
https://www.ncbi.nlm.nih.gov/pubmed/36920505
http://dx.doi.org/10.1097/FTD.0000000000001050
Descripción
Sumario:Therapeutic drug monitoring (TDM) results for ganciclovir in 12 different treatment episodes showed large intraindividual and interindividual variabilities in the trough concentration and area under the 24-hour concentration–time curve (AUC24). Despite adequate valganciclovir dosing, subtherapeutic concentrations were found in 30% of the treatment episodes. A decrease in viral load was observed regardless of subtherapeutic exposure. These findings show the need for target concentration evaluation and assessment of the applicability of ganciclovir TDM in children.

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