Orf virus induces complete autophagy to promote viral replication via inhibition of AKT/mTOR and activation of the ERK1/2/mTOR signalling pathway in OFTu cells

Orf virus (ORFV) is the causative agent of contagious ecthyma, which is an important zoonotic pathogen with a widespread distribution affecting sheep, goats and humans. Our previous research showed that autophagy can be induced in host cells by ORFV infection. However, the exact mechanism of ORFV-in...

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Detalles Bibliográficos
Autores principales: Lv, Lijun, Guan, Jiyu, Zhen, Ruixue, Lv, Pin, Xu, Mengshi, Liu, Xingyuan, He, Shishi, Fang, Ziyu, Li, Zi, Lan, Yungang, Lu, Huijun, He, Wenqi, Gao, Feng, Zhao, Kui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013242/
https://www.ncbi.nlm.nih.gov/pubmed/36918891
http://dx.doi.org/10.1186/s13567-023-01153-1

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