HLA-Bw4 in association with KIR3DL1 favors natural killer cell-mediated protection against severe COVID-19

Replicating SARS-CoV-2 has been shown to degrade HLA class I on target cells to evade the cytotoxic T-cell (CTL) response. HLA-I downregulation can be sensed by NK cells to unleash killer cell immunoglobulin-like receptor (KIR)-mediated self-inhibition by the cognate HLA-I ligands. Here, we investig...

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Detalles Bibliográficos
Autores principales: Wang, Ruihua, Sun, Ying, Kuang, Bo-Hua, Yan, Xiao, Lei, Jinju, Lin, Yu-Xin, Tian, Jinxiu, Li, Yating, Xie, Xiaoduo, Chen, Tao, Zhang, Hui, Zeng, Yi-Xin, Zhao, Jincun, Feng, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Coronaviruses
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013568/
https://www.ncbi.nlm.nih.gov/pubmed/36849422
http://dx.doi.org/10.1080/22221751.2023.2185467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013568/
https://www.ncbi.nlm.nih.gov/pubmed/36849422
http://dx.doi.org/10.1080/22221751.2023.2185467

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