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HLA-Bw4 in association with KIR3DL1 favors natural killer cell-mediated protection against severe COVID-19
Replicating SARS-CoV-2 has been shown to degrade HLA class I on target cells to evade the cytotoxic T-cell (CTL) response. HLA-I downregulation can be sensed by NK cells to unleash killer cell immunoglobulin-like receptor (KIR)-mediated self-inhibition by the cognate HLA-I ligands. Here, we investig...
Autores principales: | Wang, Ruihua, Sun, Ying, Kuang, Bo-Hua, Yan, Xiao, Lei, Jinju, Lin, Yu-Xin, Tian, Jinxiu, Li, Yating, Xie, Xiaoduo, Chen, Tao, Zhang, Hui, Zeng, Yi-Xin, Zhao, Jincun, Feng, Lin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013568/ https://www.ncbi.nlm.nih.gov/pubmed/36849422 http://dx.doi.org/10.1080/22221751.2023.2185467 |
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