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Adverse Events and Drug Resistance in Critically Ill Patients Treated with Colistimethate Sodium: A Review of the Literature
The adverse events related to sodium colistimethate have had variability regarding the prevalence of nephrotoxicity, neurotoxicity, and less frequent respiratory depression. In recent years, its use has been relevant due to the increase of multidrug-resistant bacteria since it is considered the last...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013588/ https://www.ncbi.nlm.nih.gov/pubmed/36925725 http://dx.doi.org/10.2147/IDR.S398930 |
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author | Ahumada Topete, Victor Hugo de Dios Sanchez, Kevin Jesus Casas Aparicio, Gustavo Alejandro Hernandez Silva, Graciela Lopez Vejar, Cesar Emmanuel Torres Espíndola, Luz Maria Aquino-Galvez, Arnoldo Rodriguez Ganen, Odalis Castillejos Lopez, Manuel de Jesus |
author_facet | Ahumada Topete, Victor Hugo de Dios Sanchez, Kevin Jesus Casas Aparicio, Gustavo Alejandro Hernandez Silva, Graciela Lopez Vejar, Cesar Emmanuel Torres Espíndola, Luz Maria Aquino-Galvez, Arnoldo Rodriguez Ganen, Odalis Castillejos Lopez, Manuel de Jesus |
author_sort | Ahumada Topete, Victor Hugo |
collection | PubMed |
description | The adverse events related to sodium colistimethate have had variability regarding the prevalence of nephrotoxicity, neurotoxicity, and less frequent respiratory depression. In recent years, its use has been relevant due to the increase of multidrug-resistant bacteria since it is considered the last-line drug, being its main adverse event and reason for discrepancies between authors’ nephrotoxicity. The indiscriminate use of antibiotic therapy has generated multiple mechanisms of resistance, the most common being related to Colistin, the bactericidal escape effect. Based on the search criteria, no randomized clinical trials were identified showing safety and efficacy with the use of Colistin, inferring that the application of the appropriate dose is governed by expert opinion and retrospective and prospective observational studies, which confounding factors such as the severity of the patient and the predisposition to develop acute renal failure are constant. In this review, we focus on identifying the mechanism of nephrotoxicity and bacterial resistance, where much remains to be known. |
format | Online Article Text |
id | pubmed-10013588 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-100135882023-03-15 Adverse Events and Drug Resistance in Critically Ill Patients Treated with Colistimethate Sodium: A Review of the Literature Ahumada Topete, Victor Hugo de Dios Sanchez, Kevin Jesus Casas Aparicio, Gustavo Alejandro Hernandez Silva, Graciela Lopez Vejar, Cesar Emmanuel Torres Espíndola, Luz Maria Aquino-Galvez, Arnoldo Rodriguez Ganen, Odalis Castillejos Lopez, Manuel de Jesus Infect Drug Resist Review The adverse events related to sodium colistimethate have had variability regarding the prevalence of nephrotoxicity, neurotoxicity, and less frequent respiratory depression. In recent years, its use has been relevant due to the increase of multidrug-resistant bacteria since it is considered the last-line drug, being its main adverse event and reason for discrepancies between authors’ nephrotoxicity. The indiscriminate use of antibiotic therapy has generated multiple mechanisms of resistance, the most common being related to Colistin, the bactericidal escape effect. Based on the search criteria, no randomized clinical trials were identified showing safety and efficacy with the use of Colistin, inferring that the application of the appropriate dose is governed by expert opinion and retrospective and prospective observational studies, which confounding factors such as the severity of the patient and the predisposition to develop acute renal failure are constant. In this review, we focus on identifying the mechanism of nephrotoxicity and bacterial resistance, where much remains to be known. Dove 2023-03-10 /pmc/articles/PMC10013588/ /pubmed/36925725 http://dx.doi.org/10.2147/IDR.S398930 Text en © 2023 Ahumada Topete et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Ahumada Topete, Victor Hugo de Dios Sanchez, Kevin Jesus Casas Aparicio, Gustavo Alejandro Hernandez Silva, Graciela Lopez Vejar, Cesar Emmanuel Torres Espíndola, Luz Maria Aquino-Galvez, Arnoldo Rodriguez Ganen, Odalis Castillejos Lopez, Manuel de Jesus Adverse Events and Drug Resistance in Critically Ill Patients Treated with Colistimethate Sodium: A Review of the Literature |
title | Adverse Events and Drug Resistance in Critically Ill Patients Treated with Colistimethate Sodium: A Review of the Literature |
title_full | Adverse Events and Drug Resistance in Critically Ill Patients Treated with Colistimethate Sodium: A Review of the Literature |
title_fullStr | Adverse Events and Drug Resistance in Critically Ill Patients Treated with Colistimethate Sodium: A Review of the Literature |
title_full_unstemmed | Adverse Events and Drug Resistance in Critically Ill Patients Treated with Colistimethate Sodium: A Review of the Literature |
title_short | Adverse Events and Drug Resistance in Critically Ill Patients Treated with Colistimethate Sodium: A Review of the Literature |
title_sort | adverse events and drug resistance in critically ill patients treated with colistimethate sodium: a review of the literature |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013588/ https://www.ncbi.nlm.nih.gov/pubmed/36925725 http://dx.doi.org/10.2147/IDR.S398930 |
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