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Global survival trends for brain tumors, by histology: Analysis of individual records for 67,776 children diagnosed in 61 countries during 2000–2014 (CONCORD-3)

INTRODUCTION: Tumors of the central nervous system are among the leading causes of cancer-related death in children. Population-based cancer survival reflects the overall effectiveness of a health care system in managing cancer. Inequity in access to care world-wide may result in survival disparitie...

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Autores principales: Girardi, Fabio, Di Carlo, Veronica, Stiller, Charles, Gatta, Gemma, Woods, Ryan R, Visser, Otto, Lacour, Brigitte, Tucker, Thomas C, Coleman, Michel P, Allemani, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013647/
https://www.ncbi.nlm.nih.gov/pubmed/36215122
http://dx.doi.org/10.1093/neuonc/noac232
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author Girardi, Fabio
Di Carlo, Veronica
Stiller, Charles
Gatta, Gemma
Woods, Ryan R
Visser, Otto
Lacour, Brigitte
Tucker, Thomas C
Coleman, Michel P
Allemani, Claudia
author_facet Girardi, Fabio
Di Carlo, Veronica
Stiller, Charles
Gatta, Gemma
Woods, Ryan R
Visser, Otto
Lacour, Brigitte
Tucker, Thomas C
Coleman, Michel P
Allemani, Claudia
author_sort Girardi, Fabio
collection PubMed
description INTRODUCTION: Tumors of the central nervous system are among the leading causes of cancer-related death in children. Population-based cancer survival reflects the overall effectiveness of a health care system in managing cancer. Inequity in access to care world-wide may result in survival disparities. METHODS: We considered children (0–14 years) diagnosed with a brain tumor during 2000–2014, regardless of tumor behavior. Data underwent a rigorous, three-phase quality control as part of CONCORD-3. We implemented a revised version of the International Classification of Childhood Cancer (third edition) to control for under-registration of non-malignant astrocytic tumors. We estimated net survival using the unbiased nonparametric Pohar Perme estimator. RESULTS: The study included 67,776 children. We estimated survival for 12 histology groups, each based on relevant ICD-O-3 codes. Age-standardized 5-year net survival for low-grade astrocytoma ranged between 84% and 100% world-wide during 2000–2014. In most countries, 5-year survival was 90% or more during 2000–2004, 2005–2009, and 2010–2014. Global variation in survival for medulloblastoma was much wider, with age-standardized 5-year net survival between 47% and 86% for children diagnosed during 2010–2014. CONCLUSIONS: To the best of our knowledge, this study provides the largest account to date of global trends in population-based survival for brain tumors in children, by histology. We devised an enhanced version of ICCC-3 to account for differences in cancer registration practices world-wide. Our findings may have public health implications, because low-grade glioma is 1 of the 6 index childhood cancers included by WHO in the Global Initiative for Childhood Cancer.
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spelling pubmed-100136472023-03-15 Global survival trends for brain tumors, by histology: Analysis of individual records for 67,776 children diagnosed in 61 countries during 2000–2014 (CONCORD-3) Girardi, Fabio Di Carlo, Veronica Stiller, Charles Gatta, Gemma Woods, Ryan R Visser, Otto Lacour, Brigitte Tucker, Thomas C Coleman, Michel P Allemani, Claudia Neuro Oncol Epidemiology INTRODUCTION: Tumors of the central nervous system are among the leading causes of cancer-related death in children. Population-based cancer survival reflects the overall effectiveness of a health care system in managing cancer. Inequity in access to care world-wide may result in survival disparities. METHODS: We considered children (0–14 years) diagnosed with a brain tumor during 2000–2014, regardless of tumor behavior. Data underwent a rigorous, three-phase quality control as part of CONCORD-3. We implemented a revised version of the International Classification of Childhood Cancer (third edition) to control for under-registration of non-malignant astrocytic tumors. We estimated net survival using the unbiased nonparametric Pohar Perme estimator. RESULTS: The study included 67,776 children. We estimated survival for 12 histology groups, each based on relevant ICD-O-3 codes. Age-standardized 5-year net survival for low-grade astrocytoma ranged between 84% and 100% world-wide during 2000–2014. In most countries, 5-year survival was 90% or more during 2000–2004, 2005–2009, and 2010–2014. Global variation in survival for medulloblastoma was much wider, with age-standardized 5-year net survival between 47% and 86% for children diagnosed during 2010–2014. CONCLUSIONS: To the best of our knowledge, this study provides the largest account to date of global trends in population-based survival for brain tumors in children, by histology. We devised an enhanced version of ICCC-3 to account for differences in cancer registration practices world-wide. Our findings may have public health implications, because low-grade glioma is 1 of the 6 index childhood cancers included by WHO in the Global Initiative for Childhood Cancer. Oxford University Press 2022-10-10 /pmc/articles/PMC10013647/ /pubmed/36215122 http://dx.doi.org/10.1093/neuonc/noac232 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Epidemiology
Girardi, Fabio
Di Carlo, Veronica
Stiller, Charles
Gatta, Gemma
Woods, Ryan R
Visser, Otto
Lacour, Brigitte
Tucker, Thomas C
Coleman, Michel P
Allemani, Claudia
Global survival trends for brain tumors, by histology: Analysis of individual records for 67,776 children diagnosed in 61 countries during 2000–2014 (CONCORD-3)
title Global survival trends for brain tumors, by histology: Analysis of individual records for 67,776 children diagnosed in 61 countries during 2000–2014 (CONCORD-3)
title_full Global survival trends for brain tumors, by histology: Analysis of individual records for 67,776 children diagnosed in 61 countries during 2000–2014 (CONCORD-3)
title_fullStr Global survival trends for brain tumors, by histology: Analysis of individual records for 67,776 children diagnosed in 61 countries during 2000–2014 (CONCORD-3)
title_full_unstemmed Global survival trends for brain tumors, by histology: Analysis of individual records for 67,776 children diagnosed in 61 countries during 2000–2014 (CONCORD-3)
title_short Global survival trends for brain tumors, by histology: Analysis of individual records for 67,776 children diagnosed in 61 countries during 2000–2014 (CONCORD-3)
title_sort global survival trends for brain tumors, by histology: analysis of individual records for 67,776 children diagnosed in 61 countries during 2000–2014 (concord-3)
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013647/
https://www.ncbi.nlm.nih.gov/pubmed/36215122
http://dx.doi.org/10.1093/neuonc/noac232
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