Cargando…

Optimizing the order of actions in a model of contact tracing

Contact tracing is a key tool for managing epidemic diseases like HIV, tuberculosis, COVID-19, and monkeypox. Manual investigations by human-contact tracers remain a dominant way in which this is carried out. This process is limited by the number of contact tracers available, who are often overburde...

Descripción completa

Detalles Bibliográficos
Autores principales: Meister, Michela, Kleinberg, Jon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013731/
https://www.ncbi.nlm.nih.gov/pubmed/36926225
http://dx.doi.org/10.1093/pnasnexus/pgad003
_version_ 1784906836971880448
author Meister, Michela
Kleinberg, Jon
author_facet Meister, Michela
Kleinberg, Jon
author_sort Meister, Michela
collection PubMed
description Contact tracing is a key tool for managing epidemic diseases like HIV, tuberculosis, COVID-19, and monkeypox. Manual investigations by human-contact tracers remain a dominant way in which this is carried out. This process is limited by the number of contact tracers available, who are often overburdened during an outbreak or epidemic. As a result, a crucial decision in any contact tracing strategy is, given a set of contacts, which person should a tracer trace next? In this work, we develop a formal model that articulates these questions and provides a framework for comparing contact tracing strategies. Through analyzing our model, we give provably optimal prioritization policies via a clean connection to a tool from operations research called a “branching bandit”. Examining these policies gives qualitative insight into trade-offs in contact tracing applications.
format Online
Article
Text
id pubmed-10013731
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-100137312023-03-15 Optimizing the order of actions in a model of contact tracing Meister, Michela Kleinberg, Jon PNAS Nexus Physical Sciences and Engineering Contact tracing is a key tool for managing epidemic diseases like HIV, tuberculosis, COVID-19, and monkeypox. Manual investigations by human-contact tracers remain a dominant way in which this is carried out. This process is limited by the number of contact tracers available, who are often overburdened during an outbreak or epidemic. As a result, a crucial decision in any contact tracing strategy is, given a set of contacts, which person should a tracer trace next? In this work, we develop a formal model that articulates these questions and provides a framework for comparing contact tracing strategies. Through analyzing our model, we give provably optimal prioritization policies via a clean connection to a tool from operations research called a “branching bandit”. Examining these policies gives qualitative insight into trade-offs in contact tracing applications. Oxford University Press 2023-01-20 /pmc/articles/PMC10013731/ /pubmed/36926225 http://dx.doi.org/10.1093/pnasnexus/pgad003 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of National Academy of Sciences. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Physical Sciences and Engineering
Meister, Michela
Kleinberg, Jon
Optimizing the order of actions in a model of contact tracing
title Optimizing the order of actions in a model of contact tracing
title_full Optimizing the order of actions in a model of contact tracing
title_fullStr Optimizing the order of actions in a model of contact tracing
title_full_unstemmed Optimizing the order of actions in a model of contact tracing
title_short Optimizing the order of actions in a model of contact tracing
title_sort optimizing the order of actions in a model of contact tracing
topic Physical Sciences and Engineering
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013731/
https://www.ncbi.nlm.nih.gov/pubmed/36926225
http://dx.doi.org/10.1093/pnasnexus/pgad003
work_keys_str_mv AT meistermichela optimizingtheorderofactionsinamodelofcontacttracing
AT kleinbergjon optimizingtheorderofactionsinamodelofcontacttracing