Long-term persistence and functionality of adoptively transferred antigen-specific T cells with genetically ablated PD-1 expression

Engagement of the inhibitory T cell receptor programmed cell death protein 1 (PD-1) associates with dysfunctional states of pathogen- or tumor-specific T cells. Accordingly, systemic antibody-mediated blockade of PD-1 has become a central target for immunotherapies but is also associated with severe...

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Detalles Bibliográficos
Autores principales: Dötsch, Sarah, Svec, Mortimer, Schober, Kilian, Hammel, Monika, Wanisch, Andreas, Gökmen, Füsun, Jarosch, Sebastian, Warmuth, Linda, Barton, Jack, Cicin-Sain, Luka, D’Ippolito, Elvira, Busch, Dirk H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013756/
https://www.ncbi.nlm.nih.gov/pubmed/36853939
http://dx.doi.org/10.1073/pnas.2200626120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013756/
https://www.ncbi.nlm.nih.gov/pubmed/36853939
http://dx.doi.org/10.1073/pnas.2200626120

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