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Fluid mechanical performance of ureteral stents: The role of side hole and lumen size

Ureteral stents are indispensable devices in urological practice to maintain and reinstate the drainage of urine in the upper urinary tract. Most ureteral stents feature openings in the stent wall, referred to as side holes (SHs), which are designed to facilitate urine flux in and out of the stent l...

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Autores principales: Zheng, Shaokai, Obrist, Dominik, Burkhard, Fiona, Clavica, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013766/
https://www.ncbi.nlm.nih.gov/pubmed/36925692
http://dx.doi.org/10.1002/btm2.10407
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author Zheng, Shaokai
Obrist, Dominik
Burkhard, Fiona
Clavica, Francesco
author_facet Zheng, Shaokai
Obrist, Dominik
Burkhard, Fiona
Clavica, Francesco
author_sort Zheng, Shaokai
collection PubMed
description Ureteral stents are indispensable devices in urological practice to maintain and reinstate the drainage of urine in the upper urinary tract. Most ureteral stents feature openings in the stent wall, referred to as side holes (SHs), which are designed to facilitate urine flux in and out of the stent lumen. However, systematic discussions on the role of SH and stent lumen size in regulating flux and shear stress levels are still lacking. In this study, we leveraged both experimental and numerical methods, using microscopic‐Particle Image Velocimetry and Computational Fluid Dynamic models, respectively, to explore the influence of varying SH and lumen diameters. Our results showed that by reducing the SH diameter from [Formula: see text] to [Formula: see text] the median wall shear stress levels of the SHs near the ureteropelvic junction and ureterovesical junction increased by over [Formula: see text] , even though the flux magnitudes through these SH decreased by about [Formula: see text]. All other SHs were associated with low flux and low shear stress levels. Reducing the stent lumen diameter significantly impeded the luminal flow and the flux through SHs. By means of zero‐dimensional models and scaling relations, we summarized previous findings on the subject and argued that the design of stent inlet/outlet is key in regulating the flow characteristics described above. Finally, we offered some clinically relevant input in terms of choosing the right stent for the right patient.
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spelling pubmed-100137662023-03-15 Fluid mechanical performance of ureteral stents: The role of side hole and lumen size Zheng, Shaokai Obrist, Dominik Burkhard, Fiona Clavica, Francesco Bioeng Transl Med Research Articles Ureteral stents are indispensable devices in urological practice to maintain and reinstate the drainage of urine in the upper urinary tract. Most ureteral stents feature openings in the stent wall, referred to as side holes (SHs), which are designed to facilitate urine flux in and out of the stent lumen. However, systematic discussions on the role of SH and stent lumen size in regulating flux and shear stress levels are still lacking. In this study, we leveraged both experimental and numerical methods, using microscopic‐Particle Image Velocimetry and Computational Fluid Dynamic models, respectively, to explore the influence of varying SH and lumen diameters. Our results showed that by reducing the SH diameter from [Formula: see text] to [Formula: see text] the median wall shear stress levels of the SHs near the ureteropelvic junction and ureterovesical junction increased by over [Formula: see text] , even though the flux magnitudes through these SH decreased by about [Formula: see text]. All other SHs were associated with low flux and low shear stress levels. Reducing the stent lumen diameter significantly impeded the luminal flow and the flux through SHs. By means of zero‐dimensional models and scaling relations, we summarized previous findings on the subject and argued that the design of stent inlet/outlet is key in regulating the flow characteristics described above. Finally, we offered some clinically relevant input in terms of choosing the right stent for the right patient. John Wiley & Sons, Inc. 2022-09-13 /pmc/articles/PMC10013766/ /pubmed/36925692 http://dx.doi.org/10.1002/btm2.10407 Text en © 2022 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Zheng, Shaokai
Obrist, Dominik
Burkhard, Fiona
Clavica, Francesco
Fluid mechanical performance of ureteral stents: The role of side hole and lumen size
title Fluid mechanical performance of ureteral stents: The role of side hole and lumen size
title_full Fluid mechanical performance of ureteral stents: The role of side hole and lumen size
title_fullStr Fluid mechanical performance of ureteral stents: The role of side hole and lumen size
title_full_unstemmed Fluid mechanical performance of ureteral stents: The role of side hole and lumen size
title_short Fluid mechanical performance of ureteral stents: The role of side hole and lumen size
title_sort fluid mechanical performance of ureteral stents: the role of side hole and lumen size
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013766/
https://www.ncbi.nlm.nih.gov/pubmed/36925692
http://dx.doi.org/10.1002/btm2.10407
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