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Microsampling tools for collecting, processing, and storing blood at the point‐of‐care

In the wake of the COVID‐19 global pandemic, self‐administered microsampling tools have reemerged as an effective means to maintain routine healthcare assessments without inundating hospitals or clinics. Finger‐stick collection of blood is easily performed at home, in the workplace, or at the point‐...

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Detalles Bibliográficos
Autores principales: Baillargeon, Keith R., Mace, Charles R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013775/
https://www.ncbi.nlm.nih.gov/pubmed/36925672
http://dx.doi.org/10.1002/btm2.10476
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author Baillargeon, Keith R.
Mace, Charles R.
author_facet Baillargeon, Keith R.
Mace, Charles R.
author_sort Baillargeon, Keith R.
collection PubMed
description In the wake of the COVID‐19 global pandemic, self‐administered microsampling tools have reemerged as an effective means to maintain routine healthcare assessments without inundating hospitals or clinics. Finger‐stick collection of blood is easily performed at home, in the workplace, or at the point‐of‐care, obviating the need for a trained phlebotomist. While the initial collection of blood is facile, the diagnostic or clinical utility of the sample is dependent on how the sample is processed and stored prior to transport to an analytical laboratory. The past decade has seen incredible innovation for the development of new materials and technologies to collect low‐volume samples of blood with excellent precision that operate independently of the hematocrit effect. The final application of that blood (i.e., the test to be performed) ultimately dictates the collection and storage approach as certain materials or chemical reagents can render a sample diagnostically useless. Consequently, there is not a single microsampling tool that is capable of addressing every clinical need at this time. In this review, we highlight technologies designed for patient‐centric microsampling blood at the point‐of‐care and discuss their utility for quantitative sampling as a function of collection material and technique. In addition to surveying methods for collecting and storing whole blood, we emphasize the need for direct separation of the cellular and liquid components of blood to produce cell‐free plasma to expand clinical utility. Integrating advanced functionality while maintaining simple user operation presents a viable means of revolutionizing self‐administered microsampling, establishing new avenues for innovation in materials science, and expanding access to healthcare.
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spelling pubmed-100137752023-03-15 Microsampling tools for collecting, processing, and storing blood at the point‐of‐care Baillargeon, Keith R. Mace, Charles R. Bioeng Transl Med Review Articles In the wake of the COVID‐19 global pandemic, self‐administered microsampling tools have reemerged as an effective means to maintain routine healthcare assessments without inundating hospitals or clinics. Finger‐stick collection of blood is easily performed at home, in the workplace, or at the point‐of‐care, obviating the need for a trained phlebotomist. While the initial collection of blood is facile, the diagnostic or clinical utility of the sample is dependent on how the sample is processed and stored prior to transport to an analytical laboratory. The past decade has seen incredible innovation for the development of new materials and technologies to collect low‐volume samples of blood with excellent precision that operate independently of the hematocrit effect. The final application of that blood (i.e., the test to be performed) ultimately dictates the collection and storage approach as certain materials or chemical reagents can render a sample diagnostically useless. Consequently, there is not a single microsampling tool that is capable of addressing every clinical need at this time. In this review, we highlight technologies designed for patient‐centric microsampling blood at the point‐of‐care and discuss their utility for quantitative sampling as a function of collection material and technique. In addition to surveying methods for collecting and storing whole blood, we emphasize the need for direct separation of the cellular and liquid components of blood to produce cell‐free plasma to expand clinical utility. Integrating advanced functionality while maintaining simple user operation presents a viable means of revolutionizing self‐administered microsampling, establishing new avenues for innovation in materials science, and expanding access to healthcare. John Wiley & Sons, Inc. 2022-12-29 /pmc/articles/PMC10013775/ /pubmed/36925672 http://dx.doi.org/10.1002/btm2.10476 Text en © 2022 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Articles
Baillargeon, Keith R.
Mace, Charles R.
Microsampling tools for collecting, processing, and storing blood at the point‐of‐care
title Microsampling tools for collecting, processing, and storing blood at the point‐of‐care
title_full Microsampling tools for collecting, processing, and storing blood at the point‐of‐care
title_fullStr Microsampling tools for collecting, processing, and storing blood at the point‐of‐care
title_full_unstemmed Microsampling tools for collecting, processing, and storing blood at the point‐of‐care
title_short Microsampling tools for collecting, processing, and storing blood at the point‐of‐care
title_sort microsampling tools for collecting, processing, and storing blood at the point‐of‐care
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013775/
https://www.ncbi.nlm.nih.gov/pubmed/36925672
http://dx.doi.org/10.1002/btm2.10476
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