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Synergy of antioxidant and M2 polarization in polyphenol‐modified konjac glucomannan dressing for remodeling wound healing microenvironment

Effective skin wound healing and tissue regeneration remain a challenge. Excessive/chronic inflammation inhibits wound healing, leading to scar formation. Herein, we report a wound dressing composed of KGM‐GA based on the natural substances konjac glucomannan (KGM) and gallic acid (GA) that accelera...

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Autores principales: Li, Huiyang, Liang, Xiaoyu, Chen, Youlu, Liu, Kaijing, Fu, Xue, Zhang, Chuangnian, Wang, Xiaoli, Yang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013815/
https://www.ncbi.nlm.nih.gov/pubmed/36925701
http://dx.doi.org/10.1002/btm2.10398
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author Li, Huiyang
Liang, Xiaoyu
Chen, Youlu
Liu, Kaijing
Fu, Xue
Zhang, Chuangnian
Wang, Xiaoli
Yang, Jing
author_facet Li, Huiyang
Liang, Xiaoyu
Chen, Youlu
Liu, Kaijing
Fu, Xue
Zhang, Chuangnian
Wang, Xiaoli
Yang, Jing
author_sort Li, Huiyang
collection PubMed
description Effective skin wound healing and tissue regeneration remain a challenge. Excessive/chronic inflammation inhibits wound healing, leading to scar formation. Herein, we report a wound dressing composed of KGM‐GA based on the natural substances konjac glucomannan (KGM) and gallic acid (GA) that accelerates wound healing without any additional drugs. An in vitro study showed that KGM‐GA could not only stimulate macrophage polarization to the anti‐inflammatory M2 phenotype but also decrease reactive oxygen species (ROS) levels, indicating excellent anti‐inflammatory properties. Moreover, in vivo studies of skin wounds demonstrated that the KGM‐GA dressing significantly improved wound healing by accelerating wound closure, collagen deposition, and angiogenesis. In addition, it was observed that KGM‐GA regulated M2 polarization, reducing the production of intracellular ROS in the wound microenvironment, which was consistent with the in vitro experiments. Therefore, this study designed a multifunctional biomaterial with biological activity, providing a novel dressing for wound healing.
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spelling pubmed-100138152023-03-15 Synergy of antioxidant and M2 polarization in polyphenol‐modified konjac glucomannan dressing for remodeling wound healing microenvironment Li, Huiyang Liang, Xiaoyu Chen, Youlu Liu, Kaijing Fu, Xue Zhang, Chuangnian Wang, Xiaoli Yang, Jing Bioeng Transl Med Research Articles Effective skin wound healing and tissue regeneration remain a challenge. Excessive/chronic inflammation inhibits wound healing, leading to scar formation. Herein, we report a wound dressing composed of KGM‐GA based on the natural substances konjac glucomannan (KGM) and gallic acid (GA) that accelerates wound healing without any additional drugs. An in vitro study showed that KGM‐GA could not only stimulate macrophage polarization to the anti‐inflammatory M2 phenotype but also decrease reactive oxygen species (ROS) levels, indicating excellent anti‐inflammatory properties. Moreover, in vivo studies of skin wounds demonstrated that the KGM‐GA dressing significantly improved wound healing by accelerating wound closure, collagen deposition, and angiogenesis. In addition, it was observed that KGM‐GA regulated M2 polarization, reducing the production of intracellular ROS in the wound microenvironment, which was consistent with the in vitro experiments. Therefore, this study designed a multifunctional biomaterial with biological activity, providing a novel dressing for wound healing. John Wiley & Sons, Inc. 2022-09-05 /pmc/articles/PMC10013815/ /pubmed/36925701 http://dx.doi.org/10.1002/btm2.10398 Text en © 2022 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Li, Huiyang
Liang, Xiaoyu
Chen, Youlu
Liu, Kaijing
Fu, Xue
Zhang, Chuangnian
Wang, Xiaoli
Yang, Jing
Synergy of antioxidant and M2 polarization in polyphenol‐modified konjac glucomannan dressing for remodeling wound healing microenvironment
title Synergy of antioxidant and M2 polarization in polyphenol‐modified konjac glucomannan dressing for remodeling wound healing microenvironment
title_full Synergy of antioxidant and M2 polarization in polyphenol‐modified konjac glucomannan dressing for remodeling wound healing microenvironment
title_fullStr Synergy of antioxidant and M2 polarization in polyphenol‐modified konjac glucomannan dressing for remodeling wound healing microenvironment
title_full_unstemmed Synergy of antioxidant and M2 polarization in polyphenol‐modified konjac glucomannan dressing for remodeling wound healing microenvironment
title_short Synergy of antioxidant and M2 polarization in polyphenol‐modified konjac glucomannan dressing for remodeling wound healing microenvironment
title_sort synergy of antioxidant and m2 polarization in polyphenol‐modified konjac glucomannan dressing for remodeling wound healing microenvironment
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013815/
https://www.ncbi.nlm.nih.gov/pubmed/36925701
http://dx.doi.org/10.1002/btm2.10398
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