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Temporal and spatial resolution of distal protein motions that activate hydrogen tunneling in soybean lipoxygenase

The enzyme soybean lipoxygenase (SLO) provides a prototype for deep tunneling mechanisms in hydrogen transfer catalysis. This work combines room temperature X-ray studies with extended hydrogen–deuterium exchange experiments to define a catalytically-linked, radiating cone of aliphatic side chains t...

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Detalles Bibliográficos
Autores principales:	Zaragoza, Jan Paulo T., Offenbacher, Adam R., Hu, Shenshen, Gee, Christine L., Firestein, Zachary M., Minnetian, Natalie, Deng, Zhenyu, Fan, Flora, Iavarone, Anthony T., Klinman, Judith P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013837/ https://www.ncbi.nlm.nih.gov/pubmed/36867685 http://dx.doi.org/10.1073/pnas.2211630120

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