FDX1-dependent and independent mechanisms of elesclomol-mediated intracellular copper delivery

Recent studies have uncovered the therapeutic potential of elesclomol (ES), a copper-ionophore, for copper deficiency disorders. However, we currently do not understand the mechanism by which copper brought into cells as ES–Cu(II) is released and delivered to cuproenzymes present in different subcel...

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Detalles Bibliográficos
Autores principales: Zulkifli, Mohammad, Spelbring, Amy N., Zhang, Yuteng, Soma, Shivatheja, Chen, Si, Li, Luxi, Le, Trung, Shanbhag, Vinit, Petris, Michael J., Chen, Tai-Yen, Ralle, Martina, Barondeau, David P., Gohil, Vishal M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013847/
https://www.ncbi.nlm.nih.gov/pubmed/36848556
http://dx.doi.org/10.1073/pnas.2216722120

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