Multifaceted role for p53 in pancreatic cancer suppression

The vast majority of human pancreatic ductal adenocarcinomas (PDACs) harbor TP53 mutations, underscoring p53’s critical role in PDAC suppression. PDAC can arise when pancreatic acinar cells undergo acinar-to-ductal metaplasia (ADM), giving rise to premalignant pancreatic intraepithelial neoplasias (...

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Detalles Bibliográficos
Autores principales: Mello, Stephano S., Flowers, Brittany M., Mazur, Pawel K., Lee, James J., Müller, Fabian, Denny, Sarah K., Ferreira, Sofia, Hanson, Kathryn, Kim, Seung K., Greenleaf , William J., Wood, Laura D., Attardi, Laura D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013849/
https://www.ncbi.nlm.nih.gov/pubmed/36848578
http://dx.doi.org/10.1073/pnas.2211937120

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