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Impact of adverse events during community-wide mass drug administration for soil-transmitted helminths on subsequent participation–a Theory of Planned Behaviour analysis

BACKGROUND: Experiencing adverse events (AEs) during mass drug administration (MDA) could affect participation in future MDAs. This study aims to understand the potential influence of AEs during a community-wide MDA (cMDA) trial for soil-transmitted helminths (STH) in India on intention to participa...

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Autores principales: Aruldas, Kumudha, Israel, Gideon John, Johnson, Jabaselvi, Titus, Angelin, Saxena, Malvika, Kaliappan, Saravanakumar Puthupalayam, Ramesh, Rohan Michael, Walson, Judd L., Means, Arianna Rubin, Ajjampur, Sitara S. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013912/
https://www.ncbi.nlm.nih.gov/pubmed/36917597
http://dx.doi.org/10.1371/journal.pntd.0011148
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author Aruldas, Kumudha
Israel, Gideon John
Johnson, Jabaselvi
Titus, Angelin
Saxena, Malvika
Kaliappan, Saravanakumar Puthupalayam
Ramesh, Rohan Michael
Walson, Judd L.
Means, Arianna Rubin
Ajjampur, Sitara S. R.
author_facet Aruldas, Kumudha
Israel, Gideon John
Johnson, Jabaselvi
Titus, Angelin
Saxena, Malvika
Kaliappan, Saravanakumar Puthupalayam
Ramesh, Rohan Michael
Walson, Judd L.
Means, Arianna Rubin
Ajjampur, Sitara S. R.
author_sort Aruldas, Kumudha
collection PubMed
description BACKGROUND: Experiencing adverse events (AEs) during mass drug administration (MDA) could affect participation in future MDAs. This study aims to understand the potential influence of AEs during a community-wide MDA (cMDA) trial for soil-transmitted helminths (STH) in India on intention to participate in future cMDAs. METHODS: This study was conducted using a multi-method quantitative and qualitative approach among 74 participants who experienced an AE during STH cMDA and the 12 participants who subsequently refused cMDA treatment of the ongoing DeWorm3 trial. Path analysis and thematic analysis guided by the Theory of Planned Behaviour, was used. PRINCIPAL FINDINGS: Among 74 individuals who reported an AE, 12% refused treatment in the cMDA immediately subsequent to their AE and 4% refused in all subsequent cMDAs. Of these 74 individuals, 59 (80%) completed a survey and eight participated in in-depth interviews. A positive attitude towards deworming and perceived ability to participate in cMDA (perceived behavioural control) were significant predictors of intention to participate in cMDA (p<0.05). A positive attitude towards cMDA was associated with caste (χ(2) = 3.83, P = 0.05), particularly among the scheduled caste/scheduled tribe (SC/ST) (62%). Perceived behavioural control in cMDA participation was associated with occupation (χ(2) = 5.02, P<0.05), with higher perceived control among those engaged in skilled occupations (78%). Intention to participate in subsequent cMDAs was associated with caste and family type (χ(2) = 3.83, P = 0.05 and χ(2) = 7.50, P<0.05 respectively) and was higher among SC/ST (62%) and those with extended families (67%). In-depth interviews demonstrated that perceived severe AEs may lead to treatment refusal in future, particularly if children were affected. CONCLUSIONS: Intention to participate in future STH cMDAs was associated with caste (SC/ST) and family type (extended families). Therefore, community mobilization messages about potential AEs and their management may need to intentionally target non-SC/ST households, nuclear families, and those engaged in unskilled occupations to increase cMDA participation given the possibility of AEs occurring. TRIAL REGISTRATION: NCT03014167, ClinicalTrials.gov.
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spelling pubmed-100139122023-03-15 Impact of adverse events during community-wide mass drug administration for soil-transmitted helminths on subsequent participation–a Theory of Planned Behaviour analysis Aruldas, Kumudha Israel, Gideon John Johnson, Jabaselvi Titus, Angelin Saxena, Malvika Kaliappan, Saravanakumar Puthupalayam Ramesh, Rohan Michael Walson, Judd L. Means, Arianna Rubin Ajjampur, Sitara S. R. PLoS Negl Trop Dis Research Article BACKGROUND: Experiencing adverse events (AEs) during mass drug administration (MDA) could affect participation in future MDAs. This study aims to understand the potential influence of AEs during a community-wide MDA (cMDA) trial for soil-transmitted helminths (STH) in India on intention to participate in future cMDAs. METHODS: This study was conducted using a multi-method quantitative and qualitative approach among 74 participants who experienced an AE during STH cMDA and the 12 participants who subsequently refused cMDA treatment of the ongoing DeWorm3 trial. Path analysis and thematic analysis guided by the Theory of Planned Behaviour, was used. PRINCIPAL FINDINGS: Among 74 individuals who reported an AE, 12% refused treatment in the cMDA immediately subsequent to their AE and 4% refused in all subsequent cMDAs. Of these 74 individuals, 59 (80%) completed a survey and eight participated in in-depth interviews. A positive attitude towards deworming and perceived ability to participate in cMDA (perceived behavioural control) were significant predictors of intention to participate in cMDA (p<0.05). A positive attitude towards cMDA was associated with caste (χ(2) = 3.83, P = 0.05), particularly among the scheduled caste/scheduled tribe (SC/ST) (62%). Perceived behavioural control in cMDA participation was associated with occupation (χ(2) = 5.02, P<0.05), with higher perceived control among those engaged in skilled occupations (78%). Intention to participate in subsequent cMDAs was associated with caste and family type (χ(2) = 3.83, P = 0.05 and χ(2) = 7.50, P<0.05 respectively) and was higher among SC/ST (62%) and those with extended families (67%). In-depth interviews demonstrated that perceived severe AEs may lead to treatment refusal in future, particularly if children were affected. CONCLUSIONS: Intention to participate in future STH cMDAs was associated with caste (SC/ST) and family type (extended families). Therefore, community mobilization messages about potential AEs and their management may need to intentionally target non-SC/ST households, nuclear families, and those engaged in unskilled occupations to increase cMDA participation given the possibility of AEs occurring. TRIAL REGISTRATION: NCT03014167, ClinicalTrials.gov. Public Library of Science 2023-03-14 /pmc/articles/PMC10013912/ /pubmed/36917597 http://dx.doi.org/10.1371/journal.pntd.0011148 Text en © 2023 Aruldas et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Aruldas, Kumudha
Israel, Gideon John
Johnson, Jabaselvi
Titus, Angelin
Saxena, Malvika
Kaliappan, Saravanakumar Puthupalayam
Ramesh, Rohan Michael
Walson, Judd L.
Means, Arianna Rubin
Ajjampur, Sitara S. R.
Impact of adverse events during community-wide mass drug administration for soil-transmitted helminths on subsequent participation–a Theory of Planned Behaviour analysis
title Impact of adverse events during community-wide mass drug administration for soil-transmitted helminths on subsequent participation–a Theory of Planned Behaviour analysis
title_full Impact of adverse events during community-wide mass drug administration for soil-transmitted helminths on subsequent participation–a Theory of Planned Behaviour analysis
title_fullStr Impact of adverse events during community-wide mass drug administration for soil-transmitted helminths on subsequent participation–a Theory of Planned Behaviour analysis
title_full_unstemmed Impact of adverse events during community-wide mass drug administration for soil-transmitted helminths on subsequent participation–a Theory of Planned Behaviour analysis
title_short Impact of adverse events during community-wide mass drug administration for soil-transmitted helminths on subsequent participation–a Theory of Planned Behaviour analysis
title_sort impact of adverse events during community-wide mass drug administration for soil-transmitted helminths on subsequent participation–a theory of planned behaviour analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013912/
https://www.ncbi.nlm.nih.gov/pubmed/36917597
http://dx.doi.org/10.1371/journal.pntd.0011148
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