Ependymal polarity defects coupled with disorganized ciliary beating drive abnormal cerebrospinal fluid flow and spine curvature in zebrafish

Idiopathic scoliosis (IS) is the most common spinal deformity diagnosed in childhood or early adolescence, while the underlying pathogenesis of this serious condition remains largely unknown. Here, we report zebrafish ccdc57 mutants exhibiting scoliosis during late development, similar to that obser...

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Detalles Bibliográficos
Autores principales: Xie, Haibo, Kang, Yunsi, Liu, Junjun, Huang, Min, Dai, Zhicheng, Shi, Jiale, Wang, Shuo, Li, Lanqin, Li, Yuan, Zheng, Pengfei, Sun, Yi, Han, Qize, Zhang, Jingjing, Zhu, Zezhang, Xu, Leilei, Yelick, Pamela C., Cao, Muqing, Zhao, Chengtian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013924/
https://www.ncbi.nlm.nih.gov/pubmed/36862758
http://dx.doi.org/10.1371/journal.pbio.3002008

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