A field-wide assessment of differential expression profiling by high-throughput sequencing reveals widespread bias

We assess inferential quality in the field of differential expression profiling by high-throughput sequencing (HT-seq) based on analysis of datasets submitted from 2008 to 2020 to the NCBI GEO data repository. We take advantage of the parallel differential expression testing over thousands of genes,...

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Detalles Bibliográficos
Autores principales: Päll, Taavi, Luidalepp, Hannes, Tenson, Tanel, Maiväli, Ülo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Meta-Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013925/
https://www.ncbi.nlm.nih.gov/pubmed/36862747
http://dx.doi.org/10.1371/journal.pbio.3002007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013925/
https://www.ncbi.nlm.nih.gov/pubmed/36862747
http://dx.doi.org/10.1371/journal.pbio.3002007

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