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Natural killer cells in COVID-19: from infection, to vaccination and therapy

Natural killer (NK) cells are among the most important innate immunity members, which are the first cells that fight against infected cells. The function of these cells is impaired in patients with COVID-19 and they are not able to prevent the spread of the disease or destroy the infected cells. Few...

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Detalles Bibliográficos
Autores principales: Zafarani, Alireza, Razizadeh, Mohammad Hossein, Pashangzadeh, Salar, Amirzargar, Mohammad Reza, Taghavi-Farahabadi, Mahsa, Mahmoudi, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013930/
https://www.ncbi.nlm.nih.gov/pubmed/36936055
http://dx.doi.org/10.2217/fvl-2022-0040
Descripción
Sumario:Natural killer (NK) cells are among the most important innate immunity members, which are the first cells that fight against infected cells. The function of these cells is impaired in patients with COVID-19 and they are not able to prevent the spread of the disease or destroy the infected cells. Few studies have evaluated the effects of COVID-19 vaccines on NK cells, though it has been demonstrated that DNA vaccines and BNT162b2 can affect NK cell response. In the present paper, the effects of SARS-CoV-2 on the NK cells during infection, the effect of vaccination on NK cells, and the NK cell-based therapies were reviewed.