Natural killer cells in COVID-19: from infection, to vaccination and therapy

Natural killer (NK) cells are among the most important innate immunity members, which are the first cells that fight against infected cells. The function of these cells is impaired in patients with COVID-19 and they are not able to prevent the spread of the disease or destroy the infected cells. Few...

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Autores principales: Zafarani, Alireza, Razizadeh, Mohammad Hossein, Pashangzadeh, Salar, Amirzargar, Mohammad Reza, Taghavi-Farahabadi, Mahsa, Mahmoudi, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013930/
https://www.ncbi.nlm.nih.gov/pubmed/36936055
http://dx.doi.org/10.2217/fvl-2022-0040
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author Zafarani, Alireza
Razizadeh, Mohammad Hossein
Pashangzadeh, Salar
Amirzargar, Mohammad Reza
Taghavi-Farahabadi, Mahsa
Mahmoudi, Mohammad
author_facet Zafarani, Alireza
Razizadeh, Mohammad Hossein
Pashangzadeh, Salar
Amirzargar, Mohammad Reza
Taghavi-Farahabadi, Mahsa
Mahmoudi, Mohammad
author_sort Zafarani, Alireza
collection PubMed
description Natural killer (NK) cells are among the most important innate immunity members, which are the first cells that fight against infected cells. The function of these cells is impaired in patients with COVID-19 and they are not able to prevent the spread of the disease or destroy the infected cells. Few studies have evaluated the effects of COVID-19 vaccines on NK cells, though it has been demonstrated that DNA vaccines and BNT162b2 can affect NK cell response. In the present paper, the effects of SARS-CoV-2 on the NK cells during infection, the effect of vaccination on NK cells, and the NK cell-based therapies were reviewed.
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spelling pubmed-100139302023-03-15 Natural killer cells in COVID-19: from infection, to vaccination and therapy Zafarani, Alireza Razizadeh, Mohammad Hossein Pashangzadeh, Salar Amirzargar, Mohammad Reza Taghavi-Farahabadi, Mahsa Mahmoudi, Mohammad Future Virol Review Natural killer (NK) cells are among the most important innate immunity members, which are the first cells that fight against infected cells. The function of these cells is impaired in patients with COVID-19 and they are not able to prevent the spread of the disease or destroy the infected cells. Few studies have evaluated the effects of COVID-19 vaccines on NK cells, though it has been demonstrated that DNA vaccines and BNT162b2 can affect NK cell response. In the present paper, the effects of SARS-CoV-2 on the NK cells during infection, the effect of vaccination on NK cells, and the NK cell-based therapies were reviewed. Future Medicine Ltd 2023-03-14 2023-02 /pmc/articles/PMC10013930/ /pubmed/36936055 http://dx.doi.org/10.2217/fvl-2022-0040 Text en © 2023 Future Medicine Ltd https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Review
Zafarani, Alireza
Razizadeh, Mohammad Hossein
Pashangzadeh, Salar
Amirzargar, Mohammad Reza
Taghavi-Farahabadi, Mahsa
Mahmoudi, Mohammad
Natural killer cells in COVID-19: from infection, to vaccination and therapy
title Natural killer cells in COVID-19: from infection, to vaccination and therapy
title_full Natural killer cells in COVID-19: from infection, to vaccination and therapy
title_fullStr Natural killer cells in COVID-19: from infection, to vaccination and therapy
title_full_unstemmed Natural killer cells in COVID-19: from infection, to vaccination and therapy
title_short Natural killer cells in COVID-19: from infection, to vaccination and therapy
title_sort natural killer cells in covid-19: from infection, to vaccination and therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013930/
https://www.ncbi.nlm.nih.gov/pubmed/36936055
http://dx.doi.org/10.2217/fvl-2022-0040
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