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microRNA‐221 rescues the loss of dopaminergic neurons in a mouse model of Parkinson's disease
BACKGROUND: Parkinson's disease (PD) is one of the most common systemic neurodegenerative diseases and is related to the loss of dopaminergic neurons in the substantia nigra. Several studies verified that microRNA (miRNAs) targeting the Bim/Bax/caspase‐3 signaling axis is involved in the apopto...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013949/ https://www.ncbi.nlm.nih.gov/pubmed/36795044 http://dx.doi.org/10.1002/brb3.2921 |
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author | Yao, Yufang Zhao, Zhiyue Zhang, Fubo Miao, Na Wang, Nan Xu, Xin Yang, Chaoping |
author_facet | Yao, Yufang Zhao, Zhiyue Zhang, Fubo Miao, Na Wang, Nan Xu, Xin Yang, Chaoping |
author_sort | Yao, Yufang |
collection | PubMed |
description | BACKGROUND: Parkinson's disease (PD) is one of the most common systemic neurodegenerative diseases and is related to the loss of dopaminergic neurons in the substantia nigra. Several studies verified that microRNA (miRNAs) targeting the Bim/Bax/caspase‐3 signaling axis is involved in the apoptosis of dopaminergic neurons in substantia nigra. In this study, we aimed to explore the role of miR‐221 in PD. METHODS: To examine the function of miR‐221 in vivo, we used a well‐established 6‐OHDA‐induced PD mouse model. Then we conducted adenovirus‐mediated miR‐221 overexpression in the PD mice. RESULTS: Our results showed that miR‐221 overexpression improved motor behavior of the PD mice. We demonstrated that overexpression of miR‐221 reduced the loss of dopaminergic neurons in the substantia nigra striatum by promoting their antioxidative and antiapoptosis capacities. Mechanistically, miR‐221 targets Bim, thus inhibiting Bim and Bax caspase‐3 mediated apoptosis signaling pathways. CONCLUSION: Our findings suggest miR‐221 participates in the pathological process of PD and might be a potential drug target and provide new insight into PD treatment. |
format | Online Article Text |
id | pubmed-10013949 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100139492023-03-15 microRNA‐221 rescues the loss of dopaminergic neurons in a mouse model of Parkinson's disease Yao, Yufang Zhao, Zhiyue Zhang, Fubo Miao, Na Wang, Nan Xu, Xin Yang, Chaoping Brain Behav Original Articles BACKGROUND: Parkinson's disease (PD) is one of the most common systemic neurodegenerative diseases and is related to the loss of dopaminergic neurons in the substantia nigra. Several studies verified that microRNA (miRNAs) targeting the Bim/Bax/caspase‐3 signaling axis is involved in the apoptosis of dopaminergic neurons in substantia nigra. In this study, we aimed to explore the role of miR‐221 in PD. METHODS: To examine the function of miR‐221 in vivo, we used a well‐established 6‐OHDA‐induced PD mouse model. Then we conducted adenovirus‐mediated miR‐221 overexpression in the PD mice. RESULTS: Our results showed that miR‐221 overexpression improved motor behavior of the PD mice. We demonstrated that overexpression of miR‐221 reduced the loss of dopaminergic neurons in the substantia nigra striatum by promoting their antioxidative and antiapoptosis capacities. Mechanistically, miR‐221 targets Bim, thus inhibiting Bim and Bax caspase‐3 mediated apoptosis signaling pathways. CONCLUSION: Our findings suggest miR‐221 participates in the pathological process of PD and might be a potential drug target and provide new insight into PD treatment. John Wiley and Sons Inc. 2023-02-16 /pmc/articles/PMC10013949/ /pubmed/36795044 http://dx.doi.org/10.1002/brb3.2921 Text en © 2023 The Authors. Brain and Behavior published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Yao, Yufang Zhao, Zhiyue Zhang, Fubo Miao, Na Wang, Nan Xu, Xin Yang, Chaoping microRNA‐221 rescues the loss of dopaminergic neurons in a mouse model of Parkinson's disease |
title | microRNA‐221 rescues the loss of dopaminergic neurons in a mouse model of Parkinson's disease |
title_full | microRNA‐221 rescues the loss of dopaminergic neurons in a mouse model of Parkinson's disease |
title_fullStr | microRNA‐221 rescues the loss of dopaminergic neurons in a mouse model of Parkinson's disease |
title_full_unstemmed | microRNA‐221 rescues the loss of dopaminergic neurons in a mouse model of Parkinson's disease |
title_short | microRNA‐221 rescues the loss of dopaminergic neurons in a mouse model of Parkinson's disease |
title_sort | microrna‐221 rescues the loss of dopaminergic neurons in a mouse model of parkinson's disease |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013949/ https://www.ncbi.nlm.nih.gov/pubmed/36795044 http://dx.doi.org/10.1002/brb3.2921 |
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