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Run-and-Tumble Dynamics and Mechanotaxis Discovered in Microglial Migration
Microglia are resident macrophage cells in the central nervous system that search for pathogens or abnormal neural activities and migrate to resolve the issues. The effective search and targeted motion of macrophages mean dearly to maintaining a healthy brain, yet little is known about their migrati...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AAAS
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013966/ https://www.ncbi.nlm.nih.gov/pubmed/36939442 http://dx.doi.org/10.34133/research.0063 |
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author | Zhang, Yiyu Wei, Da Wang, Xiaochen Wang, Boyi Li, Ming Fang, Haiping Peng, Yi Fan, Qihui Ye, Fangfu |
author_facet | Zhang, Yiyu Wei, Da Wang, Xiaochen Wang, Boyi Li, Ming Fang, Haiping Peng, Yi Fan, Qihui Ye, Fangfu |
author_sort | Zhang, Yiyu |
collection | PubMed |
description | Microglia are resident macrophage cells in the central nervous system that search for pathogens or abnormal neural activities and migrate to resolve the issues. The effective search and targeted motion of macrophages mean dearly to maintaining a healthy brain, yet little is known about their migration dynamics. In this work, we study microglial motion with and without the presence of external mechanostimuli. We discover that the cells are promptly attracted by the applied forces (i.e., mechanotaxis), which is a tactic behavior as yet unconfirmed in microglia. Meanwhile, in both the explorative and the targeted migration, microglia display dynamics that is strikingly analogous to bacterial run-and-tumble motion. A closer examination reveals that microglial run-and-tumble is more sophisticated, e.g., they display a short-term memory when tumbling and rely on active steering during runs to achieve mechanotaxis, probably via the responses of mechanosensitive ion channels. These differences reflect the sharp contrast between microglia and bacteria cells (eukaryotes vs. prokaryotes) and their environments (compact tissue vs. fluid). Further analyses suggest that the reported migration dynamics has an optimal search efficiency and is shared among a subset of immune cells (human monocyte and macrophage). This work reveals a fruitful analogy between the locomotion of 2 remote systems and provides a framework for studying immune cells exploring complex environments. |
format | Online Article Text |
id | pubmed-10013966 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | AAAS |
record_format | MEDLINE/PubMed |
spelling | pubmed-100139662023-03-15 Run-and-Tumble Dynamics and Mechanotaxis Discovered in Microglial Migration Zhang, Yiyu Wei, Da Wang, Xiaochen Wang, Boyi Li, Ming Fang, Haiping Peng, Yi Fan, Qihui Ye, Fangfu Research (Wash D C) Research Article Microglia are resident macrophage cells in the central nervous system that search for pathogens or abnormal neural activities and migrate to resolve the issues. The effective search and targeted motion of macrophages mean dearly to maintaining a healthy brain, yet little is known about their migration dynamics. In this work, we study microglial motion with and without the presence of external mechanostimuli. We discover that the cells are promptly attracted by the applied forces (i.e., mechanotaxis), which is a tactic behavior as yet unconfirmed in microglia. Meanwhile, in both the explorative and the targeted migration, microglia display dynamics that is strikingly analogous to bacterial run-and-tumble motion. A closer examination reveals that microglial run-and-tumble is more sophisticated, e.g., they display a short-term memory when tumbling and rely on active steering during runs to achieve mechanotaxis, probably via the responses of mechanosensitive ion channels. These differences reflect the sharp contrast between microglia and bacteria cells (eukaryotes vs. prokaryotes) and their environments (compact tissue vs. fluid). Further analyses suggest that the reported migration dynamics has an optimal search efficiency and is shared among a subset of immune cells (human monocyte and macrophage). This work reveals a fruitful analogy between the locomotion of 2 remote systems and provides a framework for studying immune cells exploring complex environments. AAAS 2023-03-10 2023 /pmc/articles/PMC10013966/ /pubmed/36939442 http://dx.doi.org/10.34133/research.0063 Text en https://creativecommons.org/licenses/by/4.0/Exclusive Licensee Science and Technology Review Publishing House. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Article Zhang, Yiyu Wei, Da Wang, Xiaochen Wang, Boyi Li, Ming Fang, Haiping Peng, Yi Fan, Qihui Ye, Fangfu Run-and-Tumble Dynamics and Mechanotaxis Discovered in Microglial Migration |
title | Run-and-Tumble Dynamics and Mechanotaxis Discovered in Microglial Migration |
title_full | Run-and-Tumble Dynamics and Mechanotaxis Discovered in Microglial Migration |
title_fullStr | Run-and-Tumble Dynamics and Mechanotaxis Discovered in Microglial Migration |
title_full_unstemmed | Run-and-Tumble Dynamics and Mechanotaxis Discovered in Microglial Migration |
title_short | Run-and-Tumble Dynamics and Mechanotaxis Discovered in Microglial Migration |
title_sort | run-and-tumble dynamics and mechanotaxis discovered in microglial migration |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013966/ https://www.ncbi.nlm.nih.gov/pubmed/36939442 http://dx.doi.org/10.34133/research.0063 |
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