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author Morales Pantoja, Itzy E.
Smirnova, Lena
Muotri, Alysson R.
Wahlin, Karl J.
Kahn, Jeffrey
Boyd, J. Lomax
Gracias, David H.
Harris, Timothy D.
Cohen-Karni, Tzahi
Caffo, Brian S.
Szalay, Alexander S.
Han, Fang
Zack, Donald J.
Etienne-Cummings, Ralph
Akwaboah, Akwasi
Romero, July Carolina
Alam El Din, Dowlette-Mary
Plotkin, Jesse D.
Paulhamus, Barton L.
Johnson, Erik C.
Gilbert, Frederic
Curley, J. Lowry
Cappiello, Ben
Schwamborn, Jens C.
Hill, Eric J.
Roach, Paul
Tornero, Daniel
Krall, Caroline
Parri, Rheinallt
Sillé, Fenna
Levchenko, Andre
Jabbour, Rabih E.
Kagan, Brett J.
Berlinicke, Cynthia A.
Huang, Qi
Maertens, Alexandra
Herrmann, Kathrin
Tsaioun, Katya
Dastgheyb, Raha
Habela, Christa Whelan
Vogelstein, Joshua T.
Hartung, Thomas
author_facet Morales Pantoja, Itzy E.
Smirnova, Lena
Muotri, Alysson R.
Wahlin, Karl J.
Kahn, Jeffrey
Boyd, J. Lomax
Gracias, David H.
Harris, Timothy D.
Cohen-Karni, Tzahi
Caffo, Brian S.
Szalay, Alexander S.
Han, Fang
Zack, Donald J.
Etienne-Cummings, Ralph
Akwaboah, Akwasi
Romero, July Carolina
Alam El Din, Dowlette-Mary
Plotkin, Jesse D.
Paulhamus, Barton L.
Johnson, Erik C.
Gilbert, Frederic
Curley, J. Lowry
Cappiello, Ben
Schwamborn, Jens C.
Hill, Eric J.
Roach, Paul
Tornero, Daniel
Krall, Caroline
Parri, Rheinallt
Sillé, Fenna
Levchenko, Andre
Jabbour, Rabih E.
Kagan, Brett J.
Berlinicke, Cynthia A.
Huang, Qi
Maertens, Alexandra
Herrmann, Kathrin
Tsaioun, Katya
Dastgheyb, Raha
Habela, Christa Whelan
Vogelstein, Joshua T.
Hartung, Thomas
author_sort Morales Pantoja, Itzy E.
collection PubMed
description The brain is arguably the most powerful computation system known. It is extremely efficient in processing large amounts of information and can discern signals from noise, adapt, and filter faulty information all while running on only 20 watts of power. The human brain's processing efficiency, progressive learning, and plasticity are unmatched by any computer system. Recent advances in stem cell technology have elevated the field of cell culture to higher levels of complexity, such as the development of three-dimensional (3D) brain organoids that recapitulate human brain functionality better than traditional monolayer cell systems. Organoid Intelligence (OI) aims to harness the innate biological capabilities of brain organoids for biocomputing and synthetic intelligence by interfacing them with computer technology. With the latest strides in stem cell technology, bioengineering, and machine learning, we can explore the ability of brain organoids to compute, and store given information (input), execute a task (output), and study how this affects the structural and functional connections in the organoids themselves. Furthermore, understanding how learning generates and changes patterns of connectivity in organoids can shed light on the early stages of cognition in the human brain. Investigating and understanding these concepts is an enormous, multidisciplinary endeavor that necessitates the engagement of both the scientific community and the public. Thus, on Feb 22–24 of 2022, the Johns Hopkins University held the first Organoid Intelligence Workshop to form an OI Community and to lay out the groundwork for the establishment of OI as a new scientific discipline. The potential of OI to revolutionize computing, neurological research, and drug development was discussed, along with a vision and roadmap for its development over the coming decade.
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spelling pubmed-100139722023-03-15 First Organoid Intelligence (OI) workshop to form an OI community Morales Pantoja, Itzy E. Smirnova, Lena Muotri, Alysson R. Wahlin, Karl J. Kahn, Jeffrey Boyd, J. Lomax Gracias, David H. Harris, Timothy D. Cohen-Karni, Tzahi Caffo, Brian S. Szalay, Alexander S. Han, Fang Zack, Donald J. Etienne-Cummings, Ralph Akwaboah, Akwasi Romero, July Carolina Alam El Din, Dowlette-Mary Plotkin, Jesse D. Paulhamus, Barton L. Johnson, Erik C. Gilbert, Frederic Curley, J. Lowry Cappiello, Ben Schwamborn, Jens C. Hill, Eric J. Roach, Paul Tornero, Daniel Krall, Caroline Parri, Rheinallt Sillé, Fenna Levchenko, Andre Jabbour, Rabih E. Kagan, Brett J. Berlinicke, Cynthia A. Huang, Qi Maertens, Alexandra Herrmann, Kathrin Tsaioun, Katya Dastgheyb, Raha Habela, Christa Whelan Vogelstein, Joshua T. Hartung, Thomas Front Artif Intell Artificial Intelligence The brain is arguably the most powerful computation system known. It is extremely efficient in processing large amounts of information and can discern signals from noise, adapt, and filter faulty information all while running on only 20 watts of power. The human brain's processing efficiency, progressive learning, and plasticity are unmatched by any computer system. Recent advances in stem cell technology have elevated the field of cell culture to higher levels of complexity, such as the development of three-dimensional (3D) brain organoids that recapitulate human brain functionality better than traditional monolayer cell systems. Organoid Intelligence (OI) aims to harness the innate biological capabilities of brain organoids for biocomputing and synthetic intelligence by interfacing them with computer technology. With the latest strides in stem cell technology, bioengineering, and machine learning, we can explore the ability of brain organoids to compute, and store given information (input), execute a task (output), and study how this affects the structural and functional connections in the organoids themselves. Furthermore, understanding how learning generates and changes patterns of connectivity in organoids can shed light on the early stages of cognition in the human brain. Investigating and understanding these concepts is an enormous, multidisciplinary endeavor that necessitates the engagement of both the scientific community and the public. Thus, on Feb 22–24 of 2022, the Johns Hopkins University held the first Organoid Intelligence Workshop to form an OI Community and to lay out the groundwork for the establishment of OI as a new scientific discipline. The potential of OI to revolutionize computing, neurological research, and drug development was discussed, along with a vision and roadmap for its development over the coming decade. Frontiers Media S.A. 2023-02-28 /pmc/articles/PMC10013972/ /pubmed/36925616 http://dx.doi.org/10.3389/frai.2023.1116870 Text en Copyright © 2023 Morales Pantoja, Smirnova, Muotri, Wahlin, Kahn, Boyd, Gracias, Harris, Cohen-Karni, Caffo, Szalay, Han, Zack, Etienne-Cummings, Akwaboah, Romero, Alam El Din, Plotkin, Paulhamus, Johnson, Gilbert, Curley, Cappiello, Schwamborn, Hill, Roach, Tornero, Krall, Parri, Sillé, Levchenko, Jabbour, Kagan, Berlinicke, Huang, Maertens, Herrmann, Tsaioun, Dastgheyb, Habela, Vogelstein and Hartung. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Artificial Intelligence
Morales Pantoja, Itzy E.
Smirnova, Lena
Muotri, Alysson R.
Wahlin, Karl J.
Kahn, Jeffrey
Boyd, J. Lomax
Gracias, David H.
Harris, Timothy D.
Cohen-Karni, Tzahi
Caffo, Brian S.
Szalay, Alexander S.
Han, Fang
Zack, Donald J.
Etienne-Cummings, Ralph
Akwaboah, Akwasi
Romero, July Carolina
Alam El Din, Dowlette-Mary
Plotkin, Jesse D.
Paulhamus, Barton L.
Johnson, Erik C.
Gilbert, Frederic
Curley, J. Lowry
Cappiello, Ben
Schwamborn, Jens C.
Hill, Eric J.
Roach, Paul
Tornero, Daniel
Krall, Caroline
Parri, Rheinallt
Sillé, Fenna
Levchenko, Andre
Jabbour, Rabih E.
Kagan, Brett J.
Berlinicke, Cynthia A.
Huang, Qi
Maertens, Alexandra
Herrmann, Kathrin
Tsaioun, Katya
Dastgheyb, Raha
Habela, Christa Whelan
Vogelstein, Joshua T.
Hartung, Thomas
First Organoid Intelligence (OI) workshop to form an OI community
title First Organoid Intelligence (OI) workshop to form an OI community
title_full First Organoid Intelligence (OI) workshop to form an OI community
title_fullStr First Organoid Intelligence (OI) workshop to form an OI community
title_full_unstemmed First Organoid Intelligence (OI) workshop to form an OI community
title_short First Organoid Intelligence (OI) workshop to form an OI community
title_sort first organoid intelligence (oi) workshop to form an oi community
topic Artificial Intelligence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013972/
https://www.ncbi.nlm.nih.gov/pubmed/36925616
http://dx.doi.org/10.3389/frai.2023.1116870
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