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Clinical and laboratory differences between pediatric hospitalized patients with sickle cell disease infected or not by SARS-CoV-2

OBJECTIVE: The aim of this study was to identify clinical and complete blood count differences between pediatric hospitalized patients with sickle cell disease infected or not by SARS-CoV-2 and compare the complete blood count of patients with sickle cell disease infected by SARS-CoV-2 before hospit...

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Autores principales: Elia, Gabriella Mafra, Konstantyner, Tulio, Nais, Rafaela Pilotto, dos Santos, Andreia Regina Augusto, Angel, Andrea, Braga, Josefina Aparecida Pellegrini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade de Pediatria de São Paulo 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013992/
https://www.ncbi.nlm.nih.gov/pubmed/36921171
http://dx.doi.org/10.1590/1984-0462/2023/41/2021407
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author Elia, Gabriella Mafra
Konstantyner, Tulio
Nais, Rafaela Pilotto
dos Santos, Andreia Regina Augusto
Angel, Andrea
Braga, Josefina Aparecida Pellegrini
author_facet Elia, Gabriella Mafra
Konstantyner, Tulio
Nais, Rafaela Pilotto
dos Santos, Andreia Regina Augusto
Angel, Andrea
Braga, Josefina Aparecida Pellegrini
author_sort Elia, Gabriella Mafra
collection PubMed
description OBJECTIVE: The aim of this study was to identify clinical and complete blood count differences between pediatric hospitalized patients with sickle cell disease infected or not by SARS-CoV-2 and compare the complete blood count of patients with sickle cell disease infected by SARS-CoV-2 before hospitalization and on admission. METHODS: This study was a single-center prospective cohort. Data were collected from medical records of pediatric inpatients with sickle cell disease under 18 years old infected or not with SARS-CoV-2 from the first visit to the hospital until discharge and from the last medical appointment. All patients were tested for SARS-CoV-2 by the real-time reverse transcription polymerase chain reaction. RESULTS: Among 57 pediatric patients with sickle cell disease hospitalized from March to November 2020 in a Brazilian academic hospital, 11 (19.3%) had a positive result for SARS-CoV-2. Patients infected by SARS-CoV-2 had a higher prevalence of comorbidities than the ones who were not infected (63.6 vs. 30.4%; p=0.046). During hospital stay, no clinical or complete blood count differences between groups were found. There was a decrease in eosinophil count on hospital admission in patients with sickle cell disease infected by SARS-CoV-2 (p=0.008). CONCLUSIONS: Pediatric hospitalized patients with sickle cell disease infected by SARS-CoV-2 had more comorbidities and had a decrease in eosinophil count between hospital admission and the last medical appointment.
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spelling pubmed-100139922023-03-15 Clinical and laboratory differences between pediatric hospitalized patients with sickle cell disease infected or not by SARS-CoV-2 Elia, Gabriella Mafra Konstantyner, Tulio Nais, Rafaela Pilotto dos Santos, Andreia Regina Augusto Angel, Andrea Braga, Josefina Aparecida Pellegrini Rev Paul Pediatr Original Article OBJECTIVE: The aim of this study was to identify clinical and complete blood count differences between pediatric hospitalized patients with sickle cell disease infected or not by SARS-CoV-2 and compare the complete blood count of patients with sickle cell disease infected by SARS-CoV-2 before hospitalization and on admission. METHODS: This study was a single-center prospective cohort. Data were collected from medical records of pediatric inpatients with sickle cell disease under 18 years old infected or not with SARS-CoV-2 from the first visit to the hospital until discharge and from the last medical appointment. All patients were tested for SARS-CoV-2 by the real-time reverse transcription polymerase chain reaction. RESULTS: Among 57 pediatric patients with sickle cell disease hospitalized from March to November 2020 in a Brazilian academic hospital, 11 (19.3%) had a positive result for SARS-CoV-2. Patients infected by SARS-CoV-2 had a higher prevalence of comorbidities than the ones who were not infected (63.6 vs. 30.4%; p=0.046). During hospital stay, no clinical or complete blood count differences between groups were found. There was a decrease in eosinophil count on hospital admission in patients with sickle cell disease infected by SARS-CoV-2 (p=0.008). CONCLUSIONS: Pediatric hospitalized patients with sickle cell disease infected by SARS-CoV-2 had more comorbidities and had a decrease in eosinophil count between hospital admission and the last medical appointment. Sociedade de Pediatria de São Paulo 2023-03-13 /pmc/articles/PMC10013992/ /pubmed/36921171 http://dx.doi.org/10.1590/1984-0462/2023/41/2021407 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Original Article
Elia, Gabriella Mafra
Konstantyner, Tulio
Nais, Rafaela Pilotto
dos Santos, Andreia Regina Augusto
Angel, Andrea
Braga, Josefina Aparecida Pellegrini
Clinical and laboratory differences between pediatric hospitalized patients with sickle cell disease infected or not by SARS-CoV-2
title Clinical and laboratory differences between pediatric hospitalized patients with sickle cell disease infected or not by SARS-CoV-2
title_full Clinical and laboratory differences between pediatric hospitalized patients with sickle cell disease infected or not by SARS-CoV-2
title_fullStr Clinical and laboratory differences between pediatric hospitalized patients with sickle cell disease infected or not by SARS-CoV-2
title_full_unstemmed Clinical and laboratory differences between pediatric hospitalized patients with sickle cell disease infected or not by SARS-CoV-2
title_short Clinical and laboratory differences between pediatric hospitalized patients with sickle cell disease infected or not by SARS-CoV-2
title_sort clinical and laboratory differences between pediatric hospitalized patients with sickle cell disease infected or not by sars-cov-2
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013992/
https://www.ncbi.nlm.nih.gov/pubmed/36921171
http://dx.doi.org/10.1590/1984-0462/2023/41/2021407
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